International Flavors & Fragrances Inc.

University of Florida Research Foundation, Incorporated

Monsanto Company

Yale University

Other

Johns Hopkins University

Craig B Warren

Jerry F Butler

Anna B Marin

Braja D Mookherjee

Richard A Wilson

Anubhav P Narula

Leslie C Smith

Marina A Munteanu

Marvin M Crutchfield

Victor D Papanu

Robert W Trenkle

Donald A Withycombe

Carlos Benaim

Edward S Oltarzewski

Leon Shechter

Ronald S Leight

Henry G Walter, Jr

Gary E Schwartz

Richard M Boden

Takao Yoshida

Solomon H Snyder

Ira Katz

Chee-Teck Tan

Charles Wiener

Gabriele V Ronnett

Eric P Guenin

Siew L Chung

Karen A Trotzinka

Marcel Belt

Anne M Cunningham

John Ramsbotham

Felice F Borisy

Described is a time release fragrance sachet for air freshening, particularly for use in clothing storage cabinets. The sachets comprise a container fabricated from a substance either sufficiently porous for perfumes to pass therethrough or having openings capable of permitting fragrances to pass through the walls thereof. The sachets each contain thermoplastic particles which have contained in the interstices thereof fragrance materials. The polymer particles can be foamed particles produced using chemical blowing agents or direct gas extrusion processes. Also described are methods for fabricating such sachets and methods of using same.

Time release fragrance sachet, method of using same and method of fabricating same

Described is (i) a method of repelling Musca domestica L.(Diptera:Muscidae) or Aedes aegyptae for a finite period of time from a three-dimensional space inhabitable by Musca domnestica L.(Diptera:Muscidae) or Aedes aegyptae consisting essentially of the step of exposing a three-dimensional space to an effective Musca domestica L.(Diptera:Muscidae) or Aedes aegyptae-repelling concentration and quantity of a geraniol-containing composition consisting essentially of 50-100% of geraniol with the remainder of the composition being a compound selected from the group consisting of citronellol and nerol and (ii) a method of attracting Musca domestica L.(Diptera:Muscidae) or Aedes aegyptae using lavender absolute, benzoin, dimethyl benzyl carbinyl acetate, jasmine absolute, racemic borneol, d-limonene and/or dihydrolinalool. The attractants taken alone or in combination find utility primarily as bait enhancers for acute toxins and/or trapping devices. The above-stated attractants and repellents are described to be useful as such or contained in a polymer which can be a biodegradable polymer such as compositions containing a major proportion of poly(epsilon caprolactone) homopolymers.

Insect repellent and attractant compositions and methods for using same

Described is a method of repelling Musca domestica L.(Diptera:Muscidae), Aedes aegypti, Culex nigripalpus, Aedes atlanticus, Culex salinarius, Aedes vexans, Culex spp., Simulium spp., Psoroferia ferox, Aedes infirmatus, Drosophila melanogaster, Coccinellidae, Anopheles crucians, Psoroferia columbiae, Culicoides spp., Aedes spp. and Haematobia for a finite period of time from a three dimensional space inhabited by at least one of such insect species consisting essentially of the step of exposing a three dimensional space to an effective insect species member repelling concentration and quantity of a dimethyl substituted oxymethyl cyclohexane derivative-containing composition of matter defined according to the structure: ##STR1## The above-stated repellents are described to be useful as such or contained in a polymer which can be a biodegradable polymer such as compositions containing a major proportion of poly(epsilon caprolactone) homopolymers. The above-stated repellents are also useful in conjunction with a washing soap whereby the insect repelling composition is initially admixed with a soap base; the resulting mixture is formulated into a soap article; and the resulting soap article is used in a washing procedure on a member of the mammalian species.

Use of dimethyl substituted oxymethyl cyclohexane derivatives for their

Described is a method for repelling insects by use of oxymethyl cyclohexane derivatives of the structure ##STR1## wherein Z is methylene; n is 0 or 1; each of the wavy lines represents a carbon-carbon single bond or no bond; the dashed line represents a carbon-carbon double bond or a carbon-carbon single bond; each of R.sub.2, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 are the same or different and each represents hydrogen or methyl; and R.sub.1 represents hydrogen, acetyl or ethoxycarbonyl with the provisos:

Dimethyl substituted oxymethyl cyclohexane derivatives for their insect

Described is a method of repelling Aedes aegypti for a finite period of time from a three-dimensional space inhabited by Aedes aegypti consisting essentially of the step of exposing a three-dimensional space to an effective Aedes aegypti-repelling concentration and quantity of an unsaturated aldehyde or alcohol derivative-containing composition of matter selected from the group consisting of:

Use of unsaturated aldehyde and alkanol derivatives for their mosquito

Described is (i) a method of repelling Musca domestica L.(Diptera:Muscidae) or Aedes aegyptae for a finite period of time from a three-dimensional space inhabitable by Musca domestica L.(Diptera:Muscidae) or Aedes aegyptae consisting essentially of the step of exposing a three-dimensional space to an effective Musca domestica L.(Diptera:Muscidae) or Aedes aegyptae-repelling concentration and quantity of a geraniol-containing composition consisting essentially of 50-100% of geraniol with the remainder of the composition being a compound selected from the group consisting of citronellol and nerol and (ii) a method of attracting Musca domestica L.(Diptera:Muscidae) or Aedes aegyptae using lavender absolute, benzoin, dimethyl benzyl carbinyl acetate, jasmine absolute, racemic borneol, d-limonene and/or dihydrolinalool. The attractants taken alone or in combination find utility primarily as bait enhancers for acute toxins and/or trapping devices. The above-stated attractants and repellents are described to be useful as such or contained in a polymer which can be a biodegradable polymer such as compositions containing a major proportion of poly(epsilon caprolactone) homopolymers.

Described is (i) a method of repelling Musca domestica L. (Diptera:Muscidae) or Aedes aegyptae for a finite period of time from a three-dimensional space inhabitable by Musca domestica L. (Diptera:Muscidae) or Aedes aegyptae consisting essentially of the step of exposing a three-dimensional space to an effective Musca domestica L. (Diptera:Muscidae) or Aedes aegyptae-repelling concentration and quantity of a geraniol-containing composition consisting essentially of 50-100% of geraniol with the remainder of the composition being a compound selected from the group consisting of citronellol and nerol and (ii) a method of attracting Musca domestica L. (Diptera:Muscidae) or Aedes aegyptae using lavender absolute, benzoin, dimethyl benzyl carbinyl acetate, jasmine absolute, racemic borneol, d-limonene and/or dihydrolinalool. The attractants taken alone or in combination find utility primarily as bait enhancers for acute toxins and/or trapping devices. The above-stated attractants and repellents are described to be useful as such or contained in a polymer which can be a biodegradable polymer such as compositions containing a major proportion of poly(epsilon caprolactone) homopolymers.

Described is a method of repelling Musca domestica L.(Diptera:Muscidae), Aedes aegypti, Culex nigripalpus, Aedes atlanticus, Culex salinarius, Aedes vexans, Culex spp., Simulium spp., Psoroferia ferox, Aedes infirmatus, Drosophila melanogaster, Coccinellidae, Anopheles crucians, Psoroferia columbiae, Culicoides spp., and Aedes spp. for a finite period of time consisting essentially of the step of exposing a three-dimensional space to an effective repelling concentration and quantity of geraniol or a geraniol precursor-containing composition consisting essentially of 50-100% geraniol or a geraniol precursor (e.g., geranyloxy-1,3,2-dioxaborinane, digeranyloxydimethylsilane and geranyl glycosides, for example, geranyl 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranoside) with the remainder of the composition (if indeed the composition is not 100% geraniol) being a compound selected from the group consisting of citronellol and nerol. The above-stated repellents are described to be useful as such or contained in a polymer which can be a biodegradable polymer such as compositions containing a major proportion of poly(epsilon caprolactone) homopolymers.

Insect repellent compositions and methods for using same

Described is a method for repelling insects such as houseflies, horn flies and mosquitoes using the cyclic organic alcohol defined according to the structure: ##STR1## and/or the mixture of cyclic organic carbonates defined according to the structures: ##STR2## and devices useful in carrying out such method.

Method for repelling insects using cyclic organic alcohol or carbonates

Described is a method for repelling insects by use of oxymethyl cyclohexane derivatives of the structure ##STR1## wherein Z is methylene; n is 0 or 1; each of the wavy lines represents a carbon-carbon single bond or no bond; the dashed line represents a carbon-carbon double bond or a carbon-carbon single bond; each of R.sub.2, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 are the same or different and each represents hydrogen or methyl; and R.sub.1 represents hydrogen, acetyl or ethoxycarbonyl with the provisos: (i) that n is 1 and each of the wavy lines represents a carbon-carbon single bond when R.sub.1, R.sub.2, and R.sub.6, are each hydrogen, R.sub.5, R.sub.7 and R.sub.8 are each methyl and the dashed line is a carbon-carbon single bond; (ii) n is 0 and each of the wavy lines represents no bond when R.sub.5 and R.sub.7 are each hydrogen and R.sub.6 and R.sub.8 are each methyl; (iii) R.sub.2 is methyl only when R.sub.1 is ethoxycarbonyl; and (iv) the dashed line is a carbon-carbon single bond only when R.sub.1 is hydrogen.

The present invention provides the art with methods for enhancing the sense of smell. The method involves application of an inhibitor of phosphodiesterase to the olfactory epithelium. New inhibitors can be screened using one or more phosphodiesterases isolated from olfactory mucosa. Nebulizers for applying inhibitors to the olfactory mucosa are also provided.

Inhibition of phosphodiesterase in olfactory mucosa

Described is a method of repelling Musca domestica L. (Diptera:Muscidae), Aedes aegypti, Culex nigripalpus, Aedes atlanticus, Culex salinarius, Aedes vexans, Culex spp., Simulium spp., Psoroferia ferox, Aedes infirmatus, Drosophila melanogaster, Coccinellidae, Anopheles crucians, Psoroferia columbiae, Culicoides spp., and Aedes spp. for a finite period of time from a three-dimensional space inhabitable by these insects consisting essentially of exposing a three-dimensional space to an effective concentration and quantity of geraniol or a geraniol precursor-containing composition consisting essentially of 50-100% geraniol or a geraniol precursor (e.g., geranyloxy-1,3,2-dioxaborinane, digeranyloxydimethylsilane and geranyl glycosides, for example, geranyl 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranoside) with the remainder of the composition (if indeed the composition is not 100% geraniol) being a compound selected from the group consisting of citronellol and nerol. The above-stated repellents are described to be useful as such or contained in a polymer which can be a biodegradable polymer such as compositions containing a major proportion of poly(epsilon caprolactone) homopolymers.

Described is a method of repelling Musca domestica L. (Diptera:Muscida), Aedes aegypti, Culex nigripalpus, Aedes atlanticus, Culex salinarius, Aedes vexans, Culex spp., Simulium spp., Psoroferia ferox, Aedes infirmatus, Drosophila melanogaster, Coccinellidae, Anopheles crucians, Psoroferia columbiae, Culicoides spp., Aedes spp. and Haematobia irritans [L.]for a finite period of time from a three-dimensional space inhabited by said insect species consisting essentially of the step of exposing a three-dimensional space inhabited by said insect species to an effective insect species repelling concentration and quantity of at least one dimethyl substituted oxymethyl cyclohexene derivative defined according to the structure: ##STR1## wherein R.sub.2 represents hydrogen or methyl.

Use of dimethyl substituted oxymethyl cyclohexene derivatives for their

An alcohol-free transparent perfume is disclosed containing an alcohol-free perfume base, water and a stable transparent oil-in-water microemulsion flavor concentrate formed of water, at least one hydrophobic perfume oils, at least one cationic surfactant and at least one non-ionic surfactant in the absence of lower alkanols wherein the mixing ratio of water, oil and surfactant is defined according to the shaded area of FIG. 1.

Alcohol free perfume

Described is a method for attracting the insect species Culex nigripalpus, Aedes atlanticus, Culex salinarius, Aedes vexans, Culex spp., Simulium spp., Psoroferia ferox, Aedes infirmatus, Drosophila melanogaster, Coccinellidae, Anopheles crucians, Psoroferia columbiae, Culicoides spp. and Aedes spp. using the compound having the structure: ##STR1## This attractant finds utility primarily as a bait enhancer for acute toxins and/or trapping devices.

Growing community of inventors

Rumson, NJ, United States of America

Craig B Warren