University of Michigan

USA As Represented by Secretary of the Navy

Other

University of Pennsylvania

Genetics Institute, Inc.

Arch Development Corporation

Dana-farber-cancer Institute Inc.

The Ontario Cancer Institute

Craig B Thompson

Carl H June

Gary J Nabel

Gary S Gray

Paul David Rennert

Lawrence H Boise

Wei-Xing Zong

Gabriel Nunez

Suil Kim

Gabriel Nu&ntilde;ez

Nancy M Michael

Gordon James Freeman

Hank F Kung

Tak Wah Mak

Ravi Kumar Amaravadi

Mark R Hagan

Gabriel Nuñez

Karl Ploessl

Wenchao Qu

Prashant S Chintawar

Roland Knoblauch

Colin S Duckett

Mary Ann V Accavitti

Tullia Lindsten

Mary Ann Accavitti

Daniel Bauer

Georgia Hatzivassiliou

Julian Lum

Methods of treating individuals identified as having cancer using ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of inducing apoptosis in cancer cells using an ATP citrate lyase inhibitor and/or tri-carboxylate transporter inhibitor are disclosed. of treating an individual who has cancer comprising the steps of identifying the cancer as having a high rate of aerobic glycolysis, and administering an ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of treating individuals who have cancer using compounds that inhibit the expression of ATP citrate lyase or tricarboxylate transporter are disclosed. Methods of identifying a compound with anticancer activity are disclosed.

Compositions and methods for treating cancer

The present invention is directed single diasteromers of 4-fluoroglutamine having a diastereomeric excess of at least 80%. Methods of preparing the single diastereomers are also described, as well as methods of using the single diastereomers of radiolabeled 4-fluoroglutamine as imaging agent is also described.

Single diastereomers of 4-fluoroglutamine and methods of their preparation and use

The present invention is directed to methods of using a sirolimus drug and chloroquine or a quinoline derivative in combination. Methods of use are also described.

Combination antineoplastic therapy

Methods of using phenformin to treat certain types of cancers are described.

Methods of treating cancer with phenformin

The present invention relates to a composition comprising an immortalized cell line which is deficient in the expression of one or more gene(s) of the intrinsic apoptotic pathway, selected from the group consisting of Bax, Bak, and mixtures thereof. The present invention further relates to the product of a process for producing an immortalized mouse fibroblast cell line which is deficient in the expression of Bax, Bak, and mixtures thereof. Finally, the present invention relates to a method and a kit for identifying a compound or composition which induces or blocks the extrinsic apoptotic pathway.

Immortalized mouse fibroblast cell lines deficient in Bax and/or Bak

The present invention provides methods of identifying and/or detecting anti-cancer agents. The present invention provides methods of identifying and/or detecting compounds that can activate PARP and/or induce necrosis. The present invention also provides for methods of treating cancer in an individual. The present invention also provides kits for identifying and/or detecting anti-cancer agents.

Methods of identifying anti-cancer agents and uses thereof

Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR)/CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis.

Methods for selectively enriching TH1 and TH2 cells

Method of identifying compounds that induce cell death by necrosis

Methods for treating HIV infected subjects

Methods for selectively stimulating proliferation of T cells

A method for transfecting T cells with a nucleic acid molecule comprising a gene such that the gene is expressed in the T cells is described. The T cells are stimulated and proliferating prior to introduction of the nucleic acid molecule.

Methods for transfecting T cells

The invention relates generally to compositions of and methods for obtaining and using a polypeptide other than BCL-2 that affects programmed vertebrate cell death. The invention relates as well to polynucleotides encoding those polypeptides, recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, and recombinant polypeptides. The invention further provides methods for using the isolated, recombinant polypeptides in assays designed to select and improve substances capable of altering programmed cell death for use in diagnostic, drug design and therapeutic applications.

Vertebrate apoptosis gene: compositions and methods

Growing community of inventors

Merion, PA, United States of America

Craig B Thompson