Genentech, Inc.

Foundation Medicine, Inc.

Craig Anthony Cummings

Doron Lipson

Geoffrey Alan Otto

Jie He

David Fabrizio

David Shames

Yan Li

Daniel Lieber

Shan Zhong

Mark Kennedy

Erica Beth Schleifman

Travis Clark

Sarah Margaret Shagan

The present invention provides therapeutic, diagnostic, and prognostic methods for cancer. The invention provides methods of treating a cancer, methods of determining whether an individual having a cancer is likely to respond to a treatment including an immune checkpoint inhibitor (e.g., a PD-L1 axis binding antagonist), methods of predicting responsiveness of an individual having a cancer to a treatment including an immune checkpoint inhibitor (e.g., a PD-L1 axis binding antagonist), methods of selecting a therapy for an individual having a cancer, methods of providing a prognosis for an individual having a cancer, and methods of monitoring a response of an individual having a cancer, based on a blood tumor mutational burden (bTMB) score or a maximum somatic allele frequency (MSAF) from a sample (e.g., a whole blood sample, a plasma sample, a serum sample, or a combination thereof) from the individual.

Therapeutic and diagnostic methods for cancer

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South San Francisco, CA, United States of America

Craig Anthony Cummings