Beckman Coulter, Inc.

Dh Technologies Development Pte. Ltd.

Craig A Hudson

Mark Nierzwick

Ronald Douglas Johnson

Matthew S Davis

Mark F Sauerburger

Charles M Neese

John S Snider

Chitra Kumari Ratnayake

Brian D Peterson

Sunil S Deliwala

Peter S Kotowski

Anna X Lou

Dale Alan Owens

Jane Luo

James H Reyes

Jean-Marc Rene Lucien Busnel

Clive Cheung

Tom Tran

Mark A Nierzwick

Embodiments of lab automation workstations are disclosed in which the pod that performs pipetting operations is integrated with pipette tip-loading functionality. To generate the necessary tip-loading force, a dual drive system is used that is symmetric about the Y-axis to allow for offset or partial tip box loads by dynamically centering the drive force (e.g., the tip-loading force) over the reaction load. This minimizes the need for oversized linear motion components while still allowing for the generation of high tip-loading forces needed to properly load a large number of pipette tips simultaneously.

Motion systems for loading tips

Aspects of the innovations presented herein relate to improved systems that in some embodiments perform capillary electrophoresis (CE) and CE in conjunction with electrospray ionization (ESI) as an input to a mass spectrometry system (MS). Some embodiments use a high voltage isolated CE power supply that is configured to float on the high voltage output of an ESI-MS power supply, with a protective resistance in the ESI-MS path, as well as DC/DC converter isolation and communication system isolation for the isolated CE power supply. Some embodiments additionally use a cartridge assembly integrating separation and conductive fluid capillaries with fluid cooling and protective retractable housings for the capillary end portions and for the ESI output. The protective housing may further be used with an adapter for interfacing with different MS systems.

Capillary electrophoresis-electrospray ionization-mass spectrometry system

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Brownsburg, IN, United States of America

Craig A Hudson