Protelica, Inc.

Protelix, Inc.

Craig A Hokanson

Roberto Crea

Randy Shen

Guido Cappuccilli

Peter B Kirk

David R Liston

Jun Yoon

Emanuela Zacco

Provided herein are chimeric antigen receptors (CARs) for binding with a target antigen, comprising at least one antigen specific targeting region comprising a fibronectin type 3 (FN3) domain polypeptide. Provided herein are multispecific chimeric antigen receptors for binding with two or more target antigens, comprising at least two antigen specific targeting regions comprising a fibronectin type 3 domain polypeptide. Also provided herein are compositions and methods of treatment relating to the use of subject CARs of the invention.

Fibronectin binding domain chimeric antigen receptors and methods of use thereof

Fibronectin Type III (FN3) polypeptide libraries are described, along with their use in identifying fibronectin-type binding peptides having high binding affinities, e.g., greater than 300 nM, for VEGFR2 or Axl proteins.

Universal fibronectin type III binding-domain libraries

Walk-through mutagenesis and natural-variant combinatorial fibronectin Type III (FN3) polypeptide libraries are described, along with their method of construction and use. Also disclosed are a number of high binding affinity polypeptides selected by screening the libraries against a variety of selected antigens.

Universal fibronectin Type III binding-domain libraries

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Pleasanton, CA, United States of America

Craig A Hokanson