Cephalon, Inc.

Kyowa Hakko Kogyo Co., Ltd.

Craig A Dionne

Chikara Murakata

Patricia C Contreras

Bruce A Ruggeri

Jeffry L Vaught

Sheila J Miknyoczki

Karen J Buchkovich

John Isaacs

A method of treating or preventing cancer by administering to a mammal a therapeutically effective amount of at least one anti-neurotrophin agent is described. The anti-neurotrophin agent is preferably an anti-neurotrophin antibody, an antisense molecule directed to a neurotrophin, a small organic molecule which binds a neurotrophin, or a dominant-negative mutation of a trk receptor that binds a neurotrophin. This method is particularly preferred for the treatment of prostate or pancreatic cancer. The anti-neurotrophic agents neutralize NGF, BDNF, NT-3, NT-4/5, NT-6 or NT-7 and include humanized antibodies as well as fragments thereof.

Method of treating cancer with anti-neurotrophin agents

A method of treating prostate cancer by co-administering a tyrosine kinase inhibitor such as an indolocarbazole and a chemical castration agent is disclosed. A composition containing a tyrosine kinase inhibitor and a chemical castration agent is also disclosed.

Combination of tyrosine kinase inhibitor and chemical castration to

The invention features a method of treating a pathological condition of the prostate gland, e.g., benign prostatic hypertrophy or prostate cancer, in a mammal, said method comprising administering to said mammal a therapeutic amount of the indolocarbazole compound K-252a or a preferred derivative thereof. The invention also includes novel derivatives of K-252a.

Indolocarbazole derivatives to treat a pathological condition of the

Use of indolocarbazole derivatives to treat a pathological condition of

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Harleysville, PA, United States of America

Craig A Dionne