Sapphire Energy, Inc.

Takeda Pharmaceutical Company Limited

Renew Biopharma, Inc.

Craig A Behnke

Michael Mendez

Jeffrey Alan Stafford

Brian L Goodall

Stephen W Kaldor

Zhe Li

Alex Aravanis

Benjamin Jones

Andre A Kiryanov

John S Tyhonas

Richard J Cranford

Walter Keung

Yan Poon

Shuiqin Wu

Soyan Leung Lieberman

Matthew Saunders

Kyle Botsch

Daniel J Sajkowski

David Molina

Jamie Bacher

Nicole A Heaps

Philip Lee

Karla Gonzalez

Christopher Yohn

April Brand

Described herein are variant, novel cannabinoid synthases, nucleic acids encoding same, and various uses thereof.

Variant cannabinoid synthases and methods and uses thereof

The present disclosure provides novel proteins that when over expressed in algae result in an increase or change in fatty acid and/or glycerol lipid production and/or accumulation, without a substantial decrease in the growth rate of the alga or the break down of algal components, such as chlorophyll. The present disclosure also describes methods of using the novel proteins to increase or change the production and/or accumulation of fatty acids and/or glycerol lipids in algae. In addition, these proteins are useful tools in obtaining information about the fatty acid and triacyglyceride (TAG) synthetic pathways in algae.

Transformation of algae for increasing lipid production

Disclosed herein are methods and systems for upgrading (for example, removing heteroatoms, metals, or metalloids) an oil composition derived or extracted from a biomass. The upgraded oil composition can be used to make a desired product, for example, a fuel product.

Methods of preparing oil compositions for fuel refining

Provided herein are novel ACCases and nucleotides encoding the same, that when introduced into a cell or organism results in an increase and/or accumulation of fatty acids, glycerol lipids, and/or oils in the cell or organism, and/or a change in the types of fatty acids, glycerol lipids, and/or oils that are normally present in the cell or organism. Also provided herein are organisms transformed with the novel ACCases.

Acetyl CoA carboxylases

This disclosure provides methods of designing and generating polypeptide variants that have altered properties compared to a parent polypeptide. The present disclosure provides methods of generating polypeptide variants, for example, variant isoprenoid synthases and/or variant prenyl transferases that have at least one desired property not present in the parent polypeptide. The present disclosure further provides polypeptides and polynucleotides encoding variant polypeptides, as well as vectors and host cells comprising the polynucleotides that encode the variant polypeptides. In other embodiments, the present disclosure provides methods of using the variant polypeptides to generate useful products, such as isoprenoid compounds and/or isoprenoid products.

Variant isoprenoid producing enzymes and uses thereof

The present invention provides compositions and methods for producing flocculation moieties in photosynthetic organisms. The photosynthetic organisms are genetically modified to effect production, secretion, or both, of the flocculation moieties. Also provided are methods of flocculating organisms.

Induction of flocculation in photosynthetic organisms

The invention relates to compounds having the formulae: wherein the variables are as defined herein. The invention further relates to methods of making and using these compounds, and pharmaceutical compositions, kits and articles of manufacture comprise the compounds.

Renin inhibitors

Growing community of inventors

San Diego, CA, United States of America

Craig A Behnke