Emerald Cloud Lab, Inc.

Emerald Therapeutics, Inc.

Courtney E Webster

Daniel J Kleinbaum

Brian M Frezza

George W Fraser

Jonathan K Leung

Bradley M Bond

Shayna L Hilburg

Alex M Yoshikawa

Catherine L Hofler

Robert M Teed

Ruben E Valas

Sean M Fitzgerald

Paul R Zurek

Cheri Y Li

Ben C Kline

Sergio I Villarreal

George N Stanley

Anand V Sastry

Shivani S Baisiwala

Srikant Vaithilingam

Guillaume Robichaud

Wyatt J Woodson

Yang Choo

Cameron R Lamoureux

Hayley E Buchman

Yidan Y Cong

Asuka Ota

James R McKernan

Eric Shyr

Kyla N Velaer

The disclosure provides systems and methods for conducting and managing integrated laboratory experiments. The system includes a variety of laboratory instruments that are connected to conduct a large number of different types of experiments, and an interface for a user to design experiments and adjust parameters for the experiments. Given the integration, the system can further take data from related samples and instruments for determining or adjusting certain experimental parameters for optimized experimental efficiency and results.

System and method for management, execution, and analysis of laboratory experiments

The disclosure provides systems and methods for data analysis of experimental data. The analysis can include reference data that are not directly generated from the present experiment, which reference data may be values of the experimental parameters that were either provided by a user, computed by the system with input from a user, or computed by the system without using any input from a user. Another example of such reference data may be information about the instrument, such as the calibration method of the instrument.

Laboratory experiment data exploration and visualization

A fabrication process for producing, annealing, and conjugating nucleic acid molecules is implemented, under the direction of one or more computer programs, on two or more instruments, for carrying out the process. The process can include: (a) synthesizing, on a solid support and in a plurality of reactions, at least one of a nucleic acid and a peptide nucleic acid, and cleaving the synthesized biomolecule product from the support, providing a sample of synthesized biomolecule product from each reaction of the plurality; (b) measuring, for each sample, the volume of the sample and/or the concentration of the product; (c) subjecting the product from each reaction to chromatography under conditions suitable for achieving single-base-resolution for the product, the conditions being a function of the volume and/or concentration measured in (b); and then (d) collecting and pooling, from the chromatography of (c) for each sample, peaks that correspond to the product.

Systems and methods for automated preparation of nucleic acids

Conjugated molecules are prepared that comprise a predetermined number of oligo conjugation components. The conjugated molecules also may comprise one or more detectable labels. Preparation of these molecules can be implemented according to an asymmetric or a symmetric conjugation strategy.

Preparation of oligo conjugates

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Palo Alto, CA, United States of America

Courtney E Webster