Boston Scientific Neuromodulation Corporation

William Marsh Rice University

Courtney C Lane

Andrew DiGiore

Michael A Moffitt

Rafael Carbunaru

Kristen N Jaax

Kerry A Bradley

Anne Margaret Pianca

Brett Daniel Schleicher

Thomas A Oleksyn

David K L Peterson

James Carl Makous

David Karl Lee Peterson

Todd K Whitehurst

John Michael Barker

Ellis Garai

Mark Pierre

John Matthew Swoyer

Richard G Baraniuk

Matthew Braden Flowers

Jesse D Geroy

Kevin F Kelly

Jeff Gagnon

Don Herrick Johnson

Jason N Laska

Michael B Wakin

Marco F Duarte

Dror Z Baron

Gregory Baldwin

Terry Ferrell

Dharmpal Takhar

Jim Makous

Cliff Brainard

Charles Tilden Hagan, Iv

Anne Magaret Pianca

Michael A Moffit

David KI Peterson

Kevin F Kelley

Ilan N Goodman

Matt Flowers

Andrew Digiore

A lead is configured and arranged for brain stimulation. The lead includes a proximal end and a distal end. The proximal end includes a plurality of terminals disposed at the proximal end. The distal end has a non-circular transverse cross-sectional shape and includes a plurality of electrodes disposed at the distal end. A plurality of conductive wires electrically couple at least one of the plurality of electrodes to at least one of the plurality of terminals.

Leads with non-circular-shaped distal ends for brain stimulation systems and methods of making and using

Methods of providing therapy to a patient are provided. In one method, the patient has a neuron to which a sub-threshold biological electrical stimulus is applied. The method comprises applying electrical noise energy to the neuron, wherein resonance between the biological electrical stimulus and the electrical noise energy is created, such that an action potential is propagated along the axon of the neuron. In another method, the patient has a neuron to which a supra-threshold biological electrical stimulus is applied. This method comprises applying supra-threshold electrical noise energy to the neuron, thereby preventing an action potential from being propagated along the axon of the neuron. Still another method comprises applying an electrical stimulus to a neuron, and applying supra-threshold electrical noise energy to the neuron, thereby preventing or reversing any neurological accommodation of the neuron that may occur in response to the electrical stimulus.

Method to enhance afferent and efferent transmission using noise resonance

A method and neurostimulation system for treating a patient are provided. A plurality of pulsed electrical waveforms are respectively delivered within a plurality of timing channels of the neurostimulation system, thereby treating the patient. Sets of stimulation pulses within the pulsed electrical waveforms that will potentially overlap temporally are predicted. Stimulation pulses in the respective pulsed electrical waveforms are temporally shifted in a manner that prevents overlap of the potentially overlapping pulse sets while preventing frequency locking between the timing channels.

Methods to avoid frequency locking in a multi-channel neurostimulation system using pulse shifting

A device for brain stimulation includes a lead having a longitudinal surface, a proximal end, a distal end and a lead body. The device also includes a plurality of electrodes disposed along the longitudinal surface of the lead near the distal end of the lead. The plurality of electrodes includes a first set of segmented electrodes comprising at least two segmented electrodes disposed around a circumference of the lend at a first longitudinal position along the lead; and a second set of segmented electrodes comprising at least two segmented electrodes disposed around a circumference of the lead at a second longitudinal position along the lead. The device further includes one or more conductors that electrically couple together all of the segmented electrodes of the first set of segmented electrodes.

Deep brain stimulation current steering with split electrodes

Neurostimulation systems and methods for providing therapy to a patient suffering from a symptom of a disease that latently responds to electrical stimulation therapy are provided. First electrical stimulation energy is conveyed to or from a tissue region of the patient in accordance with a first set of stimulation parameters, thereby affecting the symptom. A predetermined period of time estimated for the symptom to resolve in response to electrical stimulation therapy is allowed to elapse. Second electrical stimulation energy is conveyed to or from the tissue region in accordance with a second set of stimulation parameters different from the first set of stimulation parameters.

Automatic evaluation technique for deep brain stimulation programming

A method for determining a change in position of a neurostimulation lead relative to a stimulation target tissue of a patient is provided. The method comprises implanting a first proximity sensor on a surface of the patient, implanting a second proximity sensor on the surface of the patient, measuring a change in a distance between the first and second proximity sensors, and inferring the change in position of the lead relative to the stimulation target tissue from the measured change in distance. The method further comprises inferring an increase in a distance between the lead and the stimulation target tissue when the distance between the first and second proximity sensors increases. The method also comprises conveying electrical stimulation energy to therapeutically stimulate the stimulation target tissue, and modulating a stimulation parameter in response to the measured change in distance.

System and method for compensating for shifting of neurostimulation leads in a patient

A device for brain stimulation includes a lead having a longitudinal surface, a proximal end, a distal end and a lead body. The device also includes a plurality of electrodes disposed along the longitudinal surface of the lead near the distal end of the lead. The plurality of electrodes includes a first set of segmented electrodes comprising at least two segmented electrodes disposed around a circumference of the lead at a first longitudinal position along the lead; and a second set of segmented electrodes comprising at least two segmented electrodes disposed around a circumference of the lead at a second longitudinal position along the lead. The device further includes one or more conductors that electrically couple together all of the segmented electrodes of the first set of segmented electrodes.

The burr hole plug comprises a plug base configured for being mounted around a burr hole, and having an aperture through which an elongated medical device exiting the burr hole may pass. The burr hole plug further comprises a retainer configured for being mounted within the plug base aperture. The retainer includes a retainer support, a slot formed in the retainer support for receiving the medical device, and a clamping mechanism having a clamping bar and a flange slidably engaged with the retainer support to laterally slide the clamping bar to secure the medical device. A method comprises introducing the medical device through the burr hole, mounting the plug base around the burr hole, mounting the retainer within the plug base aperture, receiving the medical device into the slot, and sliding the slidable flange relative to the retainer support to laterally slide to secure the medical device.

Burr hole plug having sidable clamping mechanism

A lead extension for an electrical stimulation system includes a connector disposed on a first end of a body. The connector includes a housing defining at least one port. Each of the at least one ports is configured to receive a proximal end of a lead. A plurality of connector contacts are disposed in each of the at least one ports. The connector contacts are configured to electrically couple to terminals of a lead when the lead is received by the housing. A first connector flange extends outwardly from a first side of the housing. A plurality of conductors extend along a length of the lead extension and electrically couple at least one of the connector contacts to at least one terminal disposed on a second end of the body.

Systems and methods for making and using improved lead extension connectors for electrical stimulation systems

A new digital image/video camera that directly acquires random projections of the incident light field without first collecting the pixels/voxels. In one preferred embodiment, the camera employs a digital micromirror array to perform optical calculations of linear projections of an image onto pseudorandom binary patterns. Its hallmarks include the ability to obtain an image with only a single detection element while measuring the image/video fewer times than the number of pixels or voxels&#x2014;this can significantly reduce the computation required for image/video acquisition/encoding. Since the system features a single photon detector, it can also be adapted to image at wavelengths that are currently impossible with conventional CCD and CMOS imagers.

Method and apparatus for compressive imaging device

A method and external control device for preventing frequency locking in a multi-channel neurostimulation system and external control device is provided. A plurality of pulsed electrical waveforms is provided. Each of the pulsed electrical waveforms has a period and a pulse width. The greatest common divisor of the periods of the pulsed electrical waveforms is computed, and the sum of the pulse widths of the pulsed electrical waveforms is computed. A plurality of timing channels in the neurostimulation system is allowed to be programmed with the pulsed electrical waveforms if the greatest common divisor is equal to or greater than the sum.

Methods to avoid frequency locking in a multi-channel neurostimulation system using a greatest common divisor rule

A nerve stimulation lead has a distal end, a proximal end, and a longitudinal length. The nerve stimulation lead includes a plurality of electrodes disposed at the distal end, a plurality of terminals disposed at the proximal end, and a plurality of conductive wires electrically coupling the plurality of electrodes electrically to the plurality of terminals. The nerve stimulation lead also includes at least one anchoring unit disposed on the nerve stimulation lead. The at least one anchoring unit is configured and arranged for anchoring the nerve stimulation lead against a bony structure.

Anchoring units for leads of implantable electric stimulation systems and methods of making and using

A burr hole plug comprises a plug base configured for being mounted around a burr hole. The plug base includes an aperture through which an elongated medical device exiting the burr hole may pass. The burr hole plug further comprises a retainer configured for being mounted within the aperture of the plug base. The retainer further includes first and second slidable clamping mechanisms configured for securing the medical devices therebetween within the aperture of the plug base. A method comprises introducing the medical device through the burr hole, mounting a plug base around the burr hole, such that the medical device extends through the plug base aperture, mounting the retainer within the aperture of the plug base, and sliding the first and second clamping mechanisms secure the medical device therebetween.

Burr hole plug having dual slidable clamping mechanisms

A method of operating a neurostimulation device comprises outputting a pulsed electrical waveform from the neurostimulation device between a plurality of electrodes while at least one of the electrodes has a first polarity, thereby stimulating neural tissue adjacent the electrode(s), allowing the neural tissue to undergo neurological accommodation in response to the electrical energy output between the electrodes, switching the electrode(s) from the first polarity to a second polarity, outputting the pulsed electrical waveform from the neurostimulation device between the electrodes while the electrode(s) has the second polarity, thereby hyperpolarizing the neural tissue to reverse the neurological accommodation, switching the electrode(s) from the second polarity to the first polarity, and outputting the pulsed electrical waveform from the neurostimulation device between the electrodes while the electrode(s) has the first polarity, thereby stimulating the previously hyperpolarized neural tissue.

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Ventura, CA, United States of America

Courtney C Lane