University of Connecticut

Cory A Brennick

Pramod K Srivastava

Ion Mandoiu

Marmar Moussa

Mariam M George

Described herein is an unbiased method of identifying tumor rejection mediating neoepitopes (TRMNs). Putative neoepitopes from a cancer cell exome sequence from a cancer patient are putative neoepitopes are unbiased by MHC binding and/or CD8T* reactivity. By plotting the putative neoepitope ICs on one axis, and the non-mutated amino acid sequence ICs on a perpendicular axis to provide a bivariate scatter plot, novel TRMNs are identified TRMNs the neoepitopes in the bivariate scatter plot which are in the space greater than 501 nM on the x-axis and greater than 501 nM on the y-axis. Peptides and nucleic acids for expressing peptides including the TRMNs are also described.

Growing community of inventors

Farmington, CT, United States of America

Cory A Brennick