The Scripps Research Institute

Corwin Nycholat

James C Paulson

Weihsu Chen

Matthew MacAuley

Norihito Kawasaki

Shiteng Duan

Weihsu Claire Chen

Compositions and methods are described herein that are useful for treating and inhibiting allergic conditions, including reducing the incidence of mast cell mediated anaphylaxis in subjects. The compositions include a carrier that displays an antigen and a Siglec ligand that binds to a Siglec on a mast cell.

Desensitizing mast cells by co-presentation of antigens with high affinity mast cell siglec ligands

The present invention provides liposome targeting compounds for targeting cells expressing sialic acid binding Ig-like lectin (Siglec). The liposome compounds typically comprise a binding moiety that is a glycan ligand of the Siglec on the target cell. The liposome compounds also incorporate or encapsulate a biological agent (e.g., an antigen or a therapeutic agent) that can be delivered to the target cell to modulate or kill the target cell. The invention also provides methods of using the liposome targeting compounds for targeted delivery of antigen and for modulating immune cells or immune responses.

Liposome targeting compounds and related uses

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San Diego, CA, United States of America

Corwin Nycholat