American Cyanamid Company

Corris M Hofmann

Sidney Robert Safir

Joseph William Epstein

William J Fanshawe

Lantz S Crawley

Andrew S Tomcufcik

Jeffery B Press

Howard Hancock Newman

This disclosure describes novel substituted .alpha.-[5-methyl-2-pyridyl-1H-imidazol-4-yl]-1-piperazineethanols which possess hypotensive activity.

.alpha.-[5-methyl-2-(pyridinyl)-1H-imidazol-4-yl]substituted-1-p

Substituted 3-azabicyclo[3.1.0]hexanes, acid addition salts, method of use and method of preparation are described. The compounds have anxiolytic and analgesic activity.

1-Phenyl-3-azabicyclo[3.1.0]hexanes

This disclosure describes substituted 9-(4-methyl-1-piperazinyl)-4H-thieno[3,4-b][1,4]benzodiazepines which possess analgesic and anti-depressant activity and are also useful as anti-psychotic or neuroleptic agents.

4H-Thieno[3,4-b][1,4]benzodiazepines

Azabicyclohexanes, method of use and preparation of the same

Azabicyclohexanes

Phenyl and substituted phenyl 3-azabicyclo[3.1.0]-hexanes and method of preparing the same are described. They are useful as intermediates in preparing other physiologically active compounds.

Acylazabicyclohexanes

Various substituted 6-(piperazinyl)10H-pyrido[3,2-b]thieno[3,4-e][1,4]-diazepines which have demonstrated anti-psychotic activity are disclosed.

Substituted

This invention resides in the field of p-fluorobenzoylpropyl-N-heterocyclic substituted quaternary salts useful as intermediates in the preparation of 1-p-fluorophenyl-4-N-heterocyclic-1-butanols, 1-p-fluorophenyl-4-N-heterocyclic-1-butanol esters and p-fluoro-.gamma.-heterocyclic butyrophenones having neuroleptic and analgesic activity. The butanols, butanol esters and butyrophenones from the subject matter of our concurrently filed and co-pending application Ser. No. 575,846, filed May 8, 1975, incorporated herein by reference.

Para-fluorobenzoylpropyl-N-heterocyclic substituted quaternary salts

1-p-fluorophenyl-4-N-heterocyclic-1-butanols, 1-p-fluorophenyl-4-N-heterocyclic-1-butanol esters and p-fluoro-.gamma.-heterocyclic butyrophenones having neuroleptic and analgesic activity.

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Ho-Ho-Kus, NJ, United States of America

Corris M Hofmann