Evonik Degussa Gmbh

Corrinna Klopprogge

Oskar Zelder

Hartwig Schröder

Burkhard Kröger

Markus Pompejus

Stefan Haefner

Gregor Haberhauer

Isolated nucleic acid molecules, designated MR nucleic acid molecules, which encode novel MR proteins fromare described which are involved in biosynthesis of a fine chemical, e.g., methionine biosynthesis. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MR nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides methods of producing methionine from microorganisms, e.g.,, which involve culturing recombinant microorganisms which overexpress or underexpress at least one MR molecule of the invention under conditions such that methionine is produced. Also featured are methods of producing a fine chemical, e.g., methionine, which involve culturing recombinant microorganisms having selected MR genes deleted or mutated under conditions such that the fine chemical, e.g., methionine, is produced.

Method for producing methionine using a microorganism with reduced expression activity of a negative regulator of methionine biosynthesis

Isolated nucleic acid molecules, which encode novel metabolic regulatory proteins fromare described. These nucleic acid molecules are involved in the biosynthesis of a fine chemical, e.g., methionine biosynthesis. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing metabolic regulatory nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides methods of producing methionine from microorganisms, e.g.,, which involve culturing recombinant microorganisms which overexpress or underexpress at least one metabolic regulatory molecule of the invention under conditions such that methionine is produced. Also featured are methods of producing a fine chemical, e.g., methionine, which involve culturing recombinant microorganisms having selected metabolic regulatory genes deleted or mutated under conditions such that the fine chemical, e.g., methionine, is produced.

[object Object]

Growing community of inventors

Ludwigshafen, Germany

Corrinna Klopprogge