Akzo N.v.

Cornelus J Maria Van Der Ven

Pieter De Haan

Disclosed are stabilized dry chemical (e.g. pharmaceutical) compositions containing the water soluble acid addition salt of a poorly soluble basic compound (e.g. mianserin, apomorphine, chlorpromazine, imipramine, or promethazine); an excipient selected from the group consisting of microcrystalline cellulose, lactose, calcium hydrogen phosphate, and mixtures thereof; and a water soluble (&gt;2 mg/ml) alkaline stabilizer. The resulting dry compositions are relatively more bioavailable and stable than compositions not containing the water soluble alkaline stabilizer, especially after high temperature (&gt;45.degree.) granulation processes. The process for preparing the dry composition is also more 'rugged' with the added water soluble alkaline stabilizer.

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Uden, Netherlands

Cornelus J Maria Van Der Ven