Koninklijke Philips Corporation N.v.

Johnson and Johnson Vision Care, Inc.

Ric Investments, Inc.

Cornelis Petrus Hendriks

Daan Anton Van Den Ende

Mark Thomas Johnson

Roland Alexander Van De Molengraaf

Mareike K Klee

Nicolaas Petrus Willard

Joyce Van Zanten

Valentina Lavezzo

Franciscus Johannes Gerardus Hakkens

Eduard Gerard Marie Pelssers

Willem Potze

Achim Hilgers

Rudolf Maria Jozef Voncken

Rafael Wiemker

Murtaza Bulut

Thomas Koehler

Joerg Sabczynski

Steven Ernest Franklin

Willem Franke Pasveer

Sima Asvadi

David W Smith

Biju Kumar Sreedharan Nair

Manfred Mueller

Jaap Roger Haartsen

Dirk Burdinski

Roberto Buizza

Lucas Johannes Anna Maria Beckers

Denny Mathew

Gregory J Hofmann

Jason Tokarski

Thom Warmerdam

Peter Chi Fai Ho

Matthew John Lawrenson

Julian Charles Nolan

Herbert Lifka

Arjen Van Der Horst

Sander Theodoor Pastoor

Jacob Roger Haartsen

Cornelis Reinder Ronda

Edgar V Menezes

Sergei Shulepov

Gerhardus Wilhelmus Lucassen

Reinhold Wimberger-Friedl

Johan Lub

Khaled A Chehab

Godefridus Antonius Harks

Kiran Hamilton J Dellimore

Willem Auke Westerhof

Timothy A Clutterbuck

Lutz Christian Gerhardt

Marco Baragona

Bart Gottenbos

Emil George Radulescu

Anja Van De Stolpe

Alexander Franciscus Kolen

Paul Philip Thursfield

Jörg Sabczynski

Howard David Alpert

Peter Coops

Reinder Haakma

Hans Kroes

Susanne Maaike Valster

Gerardus Henricus Maria Gijsbers

Lieke Gertruda Elisabeth Cox

Michael Polkey

Milica Kovacevic Milivojevic

Frederick Maria Boekhorst

Rene Leonardus Jacobus Marie Ubachs

Karel Johannes Adrianus Van Den Aker

Franciscus Reinier Antonius Van Der Linde

Stefan Winter

Nataly Wieberneit

Marinus Karel Johannes De Jager

Melanie Jane Windridge

Raymond Van Ee

Richard Johannus Maria Van De Ven

Hernán Guillermo Morales Varela

Marjolein Irene Van Lieshout

Marc Matysek

Wim Crooijmans

Debbie Rem-Bronneberg

Rufus Eugen Deodatus Driessen

Lucas Beckers

Angela Grassi

Sandra Hoetzl

Werner Daniel Petrus Kauwenberg

Mark Metysek

Nicholaas Petrus Willard

Manfred Müller

Ronald Antonie Hovenkamp

Rita Priori

Lieke Gertrude Elisabeth Cox

Godefridus Antoniuss Harks

Steven E Franklin

A medical imaging device includes a display device; and at least one electronic processor programmed to perform an imaging method including controlling an associated medical imaging device to acquire a dynamic lung image including a time sequence of lung images depicting at least one lung of the patient; separating the dynamic lung image into a dynamic respiration image depicting density changes due to respiration and a dynamic perfusion image depicting density changes due to lung perfusion; at least one of: (i) generating a respiration delay image based on the dynamic respiration image; and (ii) generating a perfusion delay image based on the dynamic lung perfusion image; and displaying the respiration delay image and/or lung perfusion delay image on the display device.

Lung diagnosis using dynamic X-ray imaging

An intubation assistance device includes an electronic controller configured to: identify, from one or more images of a patient, information about the patient including at least a diameter of a trachea and a length of an intubation pathway; determine a recommended ETT size including an ETT diameter and an ETT depth of insertion from the determined diameter of the trachea and the determined length of the intubation pathway; and display the recommended ETT size on a display device.

Imaging-based sizing optimization of endotracheal tube for mechanical ventilation

A diaphragm measurement device includes at least one electronic processor programmed to perform a diaphragm measurement method including receiving ultrasound imaging data of a dimension of a diaphragm of a patient during inspiration and expiration while the patient undergoes mechanical ventilation therapy with a mechanical ventilator; receiving respiratory data of the patient during inspiration and expiration while the patient undergoes the mechanical ventilation therapy; calculating a diaphragm thickness metric based on the received ultrasound imaging data of the diaphragm of the patient and the received respiratory data; and displaying, on a display device, a representation of the calculated diaphragm thickness metric.

Accurate diaphragm thickness and function evaluation using ultrasound and mechanical ventilator signals

A non-transitory storage medium stores instructions readable and executable by at least one electronic processor to receive clinical data for a current patient (P); search a database of CT scans and/or patient-specific mechanical ventilation models for other patients using the clinical data for the current patient as a search criterion to identify a similar patient in the database and similar patient data (S) comprising a CT scan and/or a patient-specific mechanical ventilation model for the similar patient; determine a patient-specific mechanical ventilation model for the current patient based on the CT scan and/or patient-specific mechanical ventilation model for the similar patient; generate ventilator configuration data for mechanically ventilating the current patient based on the determined patient-specific mechanical ventilation model for the current patient.

Mechanical ventilator configuration for mechanical ventilation of a patient with limited or no imaging data of the patient

A method is provided for recording or representing captured ultrasound-derived information. The method is based on obtaining positioning information related to an ultrasound probe during execution of an ultrasound examination, and using this to associate captured data samples, or information derived therefrom, with anatomical position information for the data samples. The link between the two is achieved using an anatomical model which can relate probe surface position with anatomical body structure underlying the surface. A map can be generated of the obtained data as a function of position across the surface of the anatomical body. i.e. effectively a projection of the data onto the object 2D surface.

Method for use in ultrasound imaging

A method of developing a personalized digital model of an anatomy of a person by a computer system comprising a processor arrangement and a communication module. The processor arrangement receives input data on an actual physical condition of the person from the communication module; searches a database of digital models modelling different physical conditions and selects a digital model from said database that closely matches the actual physical condition of the person based on some received input data; personalizes the selected digital model by developing the modelled physical condition of the selected digital model with a physiological development model based on received input data such that the developed modelled physical condition closely resembles said actual physical condition; and generates an output of the personalized digital model of said person on a data storage medium. Also disclosed, a computer program product and computer system for implementing the method.

Digital twin of a person

A mechanical ventilation device comprising at least one electronic controller is configured to receive images of lungs of a patient undergoing mechanical ventilation therapy with a mechanical ventilator, the images being acquired over time and having timestamps; process the images to generate timeline images at corresponding discrete time points; and display a timeline of the timeline images on a display device.

Inter- and extrapolation of chest image and mechanical ventilation settings into a time lapse series for progression monitoring and outcome prediction during long term mechanical ventilation

A system for predicting the onset of a physiological condition of a subject combines an in-vitro subject model having input parameters relating to actual or predicted external stimuli to which the subject is or may be exposed and an in-silico model. The in-vitro model outputs subject-specific parameters which are not being monitored, or cannot be monitored, in-vivo. The in-silico subject model uses subject-specific parameters to predict the response of the subject to the actual or predicted external stimuli and thereby predict an onset of a physiological condition of the subject.

Predicting the onset of a physiological condition of a subject using a digital biophysical model

Embodiments are described herein for training machine learning models using digital twin outputs, including for purposes of pain quantification and estimation. In various embodiments, simulation parameter(s) may be applied to a digital twin created for a subject. The digital twin may simulate an anatomical structure of the subject, and the simulation parameter(s) may cause the digital twin to generate digital twin output that simulates behavior of the anatomical structure in response to the one or more simulation parameters. Data indicative of the digital twin output may be applied as input across a pain estimation machine learning model to generate pain estimation output. Based on the pain estimation output, a quantification of pain, e.g., an estimated pain score, may be rendered using an output device and/or used to select a treatment plan.

Quantification and estimation based on digital twin output

An intubation assistance device includes an electronic controller configured to: generate a patient respiratory tract geometry model of at least a portion of a human respiratory tract by inputting one or more patient variables into a statistical shape model (SSM) of at least a portion of the human respiratory tract; select a recommended endotracheal tube (ETT) size by modeling at least one ETT model inserted into the patient respiratory tract geometry model to form a virtual fit model and estimating at least one fit parameter based on the virtual fit model; and display the recommended ETT size on a display device.

Endotracheal tube size selection and insertion depth estimation using statistical shape modelling and virtual fitting

A biological cell preservation or culturing arrangement () comprises a chamber defining a fluid retaining space () for retaining in use a body of fluid () and a deformable membrane () in communication with the fluid retaining space, and being manipulable by an electroactive polymer actuator arrangement () to undergo a defined topology change to induce in the fluid a pattern of fluid flow by which fluid is exchanged between a sub-region () immediately proximal the deformable membrane and a sub-region () removed from the deformable membrane.

Cell preservation or culturing arrangement

A computer system is disclosed comprising a processor arrangement communicatively coupled to a data storage arrangement storing a digital model of a section of a lumen system of a patient; and a communication module communicatively coupled to said processor arrangement and arranged to receive sensor data pertaining to an internal parameter of said lumen system from a sensor within said section of the lumen system. The processor arrangement is arranged to receive said sensor data from the communication module; retrieve said digital model from the data storage arrangement; simulate an actual physical condition of said lumen system by developing said digital model based on the received sensor data; and generate an output relating to said simulated actual physical condition for updating an electronic device. Also disclosed is a method of monitoring a patient with such a computer system, a computer program product for implementing such a method and a patient monitoring system.

Patient lumen system monitoring

A contact lens incorporating one or more surface modified zones on the anterior surface of the lens may be utilized to generate a friction driven rotational force when the upper and/or lower eyelids pass over the one or more regions during blinking. A small difference in the coefficient of friction between the modified and unmodified regions of the lens may result in an equivalent rotational force to that of a thickness gradient lens. This small difference in the coefficient of friction produces a means to orient and stabilize the contact lens on eye.

Friction stabilized contact lenses

Skin-contact products with a transpiration function such as medical devices or medicinal products, of which face masks, aspirators, ventilators, breast pumps or wound dressings are examples are described especially a skin-contact product with a transpiration function with an improved microclimate at a patient interface material-skin contact area. In an embodiment a material system is described that comprises a hydrophobic silicone base material and a hydrophilic silicone material that is combined with the hydrophobic base material.

Skin-contact product having moisture and microclimate control

An actuator device has a temperature sensing means and a controller adapted to apply a high frequency AC signal to stimulate internal self-heating to thereby maintain a temperature of an actuator member of the device at a certain fixed temperature, this temperature being elevated with respect to an initial temperature of the actuator member. This ensures that thermal drift may be mitigated or eliminated by compensating for any changes in environmental temperature through raising or lowering the level of the heating signal.

Actuator device and method for limiting thermal drift

Growing community of inventors

Eindhoven, Netherlands

Cornelis Petrus Hendriks