Dsm IP Assets B.v.

Cornelis Marinus Muijlwijk

Rene Marcel De Jong

Petrus Jacobus Theodorus Dekker

René Marcel De Jong

Michael Dennis Tabeling

De Jong

Petrus Jacobus Dekker

De René Marcel Jong

A variant polypeptide having chymosin activity, wherein the variant has an amino acid sequence which, when aligned with the chymosin comprising the sequence set out in SEQ ID NO: 2, comprises at least one substitution of an amino acid residue corresponding to any of amino acids 2, 22, 40, 48, 50, 51, 53, 61, 62, 76, 88, 98, 99, 109, 112, 117, 125, 126, 135, 144, 160, 161, 163, 187, 189, 194, 200, 201, 202, 203, 221, 223, 240, 242, 244, 254, 267, 271, 273, 278, 280, 284, 289, 292, 294 or 295

Chymosine enzyme variants

The invention relates to a polypeptide having chymosin activity which: a. is capable of hydrolyzing bovine alpha s1-casein at position F23F24 so as to form &#x3b1;s1-I CN (f24-199) more rapidly than camel chymosin; and b. has a C/P ratio higher than the C/P ratio of bovine chymosin.

Modified chymosin polypeptides

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Echt, Netherlands

Cornelis Marinus Muijlwijk