Academisch Ziekenhuis Leiden (h.o.d.n. Lumc)

Isa Pharmaceuticals B.v.

Stichting Voor De Technische Wetenschappen

Academisch Ziekenhuis Bij De Universiteit Van Amsterdam

Cornelis Joseph Maria Melief

Wilhelmus Johannes Theodorus Alexander Krebber

Johan Herman Kessler

Kitty Michelle Corinne Kwappenberg

Jan Wouter Drijfhout

Ferdinand Antonius Ossendorp

Wiete Westerhof

Rosalie Margaretha Luiten

The present invention relates to the fields of medicine and immunology. In particular, it relates to novel peptides that may be used in the treatment and/or prevention of a Hepatitis B viral infection and/or an Hepatitis B related disease or condition.

Synthetic long peptides (SLP) for therapeutic vaccination against Hepatitis B virus infection

Synthetic long peptides (SLP) for therapeutic vaccination against hepatitis B virus infection

The present invention relates to conjugates comprising a peptide of at least 10 amino acid residues comprising the amino acid sequence GITELKKL (residues 383-390 of SEQ ID NO: 3) for induction of potent humoral and cellular immune responses when administered to subjects having antibodies against tetanus toxoid. In one embodiment the invention relates to a prophylactic and therapeutic vaccine and in a further embodiment the invention relates to the treatment or prevention of cancer or an infectious disease.

Peptides, conjugates and method for increasing immunogenicity of a vaccine

The metabolization of certain phenols, monophenols or benzenediols into reactive quinone compounds, in particular ortho-quinones and related reactive intermediates, which is brought about by oxidation of monophenols and benzenediols by proteins exhibiting tyrosinase activity, such as human tyrosinase and the related proteins TRP1 and TRP2. The compounds function as haptens that become covalently bound to the tyrosinase enzymes, in particular to histidine moieties, in or near the catalytic site of proteins exhibiting tyrosinase activity, such as tyrosinase, TRP1 and TRP2. An immune response is then to be mounted against these haptenized auto-antigens to treat malignancies.

Monophenols and benzenediols sensitization of immune system against haptenized melanoma antigens

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Haarlem, Netherlands

Cornelis Joseph Maria Melief