Medspray B.v.

Vycap, B.v.

Aquamarijn Holding B.v.

Other

Medspray Xmems B.v.

Nanomi B.v.

Viatar LLC

Mst Microsieve Technologies Gmbh

Medspray Xemems B.v.

Cornelis Johannes Maria Van Rijn

Wietze Nijdam

Wilhelmus Petrus Johannes De Kruijf

Jeroen Mathijn Wissink

Henri Joseph Van Egmond

Iwan Rutger Heskamp

Leonardus Wendelinus Mathias Marie Terstappen

Arjan Gerhardus Johannes Tibbe

Franz Liebermann

Henri Van Egmond

Matthias Wessling

Gerrit Jan Veldhuis

Ilan K Reich

Christiaan Haldir Goeting

Antje Spors

Laurent Robert Bronner

Laura Vogelaar

Jonathan Nathaniel Barsema

Jacob Baggerman

The present invention provides a spray device that generates a fluidic micro-jet spray and that allows and retains a relatively narrow droplet size distribution, of micro-jets and droplets obtained via the Rayleigh breakup mechanism, under a well-defined control of coalescence. To tint end a spray device is characterized in that a spray nozzle unit is formed by a nozzle body (), comprising a support body () with at least one cavity () spanned by a membrane layer () having a nozzle orifice throughout a thickness of said membrane layer at an area of said cavity () in fluid communication with that cavity (). The nozzle orifice may be part of a first relatively dense group of first orifices () or of a less dense second group of second nozzle orifices () in the membrane layer. A mean diameter of the nozzle orifices () located in the first group substantially differs from the mean diameter of the nozzle orifices () in the second group to obtain a uniform droplet size distribution in the spray.

Spray device for generating a micro-jet spray

An atomizer device for atomizing a liquid under increased pressure, comprising an atomizer bodywith one or more atomizing openings from which a mist formed from the liquid escapes during operation. The device comprises a valve deviceupstream of the atomizer body. The valve devicecomprises a valve cavitywith a valve bodyand a spring chamberin which spring meansare compressible counter to a spring tension. The valve bodyreceives the liquid in valve cavitywith a first operative cross-section D, which first operative cross-section is smaller than a second operative cross-section Dof spring chamberin which spring meansare compressible.

Atomizer device

The invention relates to a spray device having a spray nozzle unit and at least one further spray nozzle unit. Each spray nozzle unit has at least one spray nozzle body, wherein at least one spray nozzle body comprises a chamber for receiving a pressurized fluid. The chamber is bound by a spray wall having at least one spray orifice that extends through the spray wall and opens to an external environment. Each of at least one orifice in a spray wall has a substantially identical predetermined size lying in a predetermined range and releases a mono disperse spray jet of the pressurized fluid fed from the associated reservoir. The range within the first spray nozzle unit differs from the range within at least one further spray nozzle unit; particularly, the ranges do not overlap.

Spray device, spray unit and spray cartridge

A spray device has a spray nozzle unit (), wherein said spray nozzle unit () comprises a cavity () with an inlet () for receiving a pressurized liquid at an operating pressure and an outlet () for releasing a liquid spray during operation. A spray nozzle body () is fitted sealingly within said cavity (), having a perforated nozzle layer () with at least one spray orifice () that extends between an upstream surface and a down stream surface thereof releasing at least one jet of said liquid spray at said downstream surface of said nozzle layer. The spray nozzle unit () is provided with a pressure safety device () upstream of said spray nozzle body (). Said pressure safety device () comprises a closed burst layer () that closes a fluid pathway between said inlet () and said spray nozzle body () but ruptures once a threshold pressure is exceeded. Said operating pressure exceeds said threshold pressure.

Spray device and spray nozzle unit

A method for manufacturing an spray device includes assembling at least one spray nozzle plate into a thermoplastic holder, while controlling the temperature of the spray nozzle plate and/or the holder and as a result at least locally plastically deforming the holder permanently. After the thermoplastic deformation of a seat of the holder, a diameter of the seat of the holder upstream of the spray nozzle plate exceeds a diameter of the seat of the holder downstream of the nozzle plate. The thermoplastic holder may have a tapered seat, where the smallest cross section of the tapered seat is smaller than the spray nozzle plate, where a widest side of the tapered seat is pointing towards a supply side of the liquid.

Aerosol or spray device, spray nozzle unit and method of manufacturing the same

The present invention relates to a spray of microjets emanating at an inclined angle from nozzles comprised in a substantially planar membrane layer. A spray nozzle unit for spraying a plurality of fluidic microjets from a pressurized liquid comprises a substantially planar (semiconductor) support having an upstream surface and a downstream surface, and a spray membrane layer arranged on the downstream surface of the support. The spray membrane layer comprises a plurality of nozzle orifices each configured for spraying a fluidic microjet in a Rayleigh regime. Thee support defines a cavity extending from the upstream surface to the spray membrane layer. The cavity is in fluid communication with each one of the nozzle orifices for supplying the pressurized liquid to the nozzle orifices. A position of the nozzle orifices, seen along a direction perpendicular to the downstream surface, is offset in respect of a centre of the cavity. At least two of the nozzle orifices exhibit a different offset in respect of the centre of the cavity.

Spray device and spray nozzle body

The present invention relates to a spray device, comprising a spray nozzle body () and a substantially planar membrane layer () suspended over a nozzle cavity () to generate microjets, especially for pharmaceutical applications, in particular preservative free formulations. The nozzle body () contains a microbial barrier, particularly a microvalve () between a fluid supply channel () and said cavity ().

Fluidic sprayer

The invention relates to a device for the microfiltration, ultrafiltration, or nanofiltration and/or the emulsification of liquids. The device has at least one rotatable membrane medium, which has a filtrate/permeate side or a side facing a dispersed phase and a concentrate/retentate side or a side facing a coherent phase and which can be rotated in a container in order to produce a vacuum on an unfiltered liquid side or the side facing the coherent phase on partial regions of the at least one rotatable membrane medium in the container in small time segments at a frequency of 1-100 Hz. Said container has at least one feed for an unfiltered liquid or the coherent phase, at least one overflow for an unfiltered liquid or an emulsion, and at least one rotatable channel for filtrate/permeate drainage or feed of the dispersed phase, and a suction device, in particular in the manner of a suction strip or nozzle plate. The suction device has at least one suction strip or nozzle plate arranged parallel to the rotatable membrane medium or is such a suction strip or nozzle plate, which is attached at a distance of less than 0.1 to 10 mm from the membrane medium, and thus cleans non-permeating materials collected on the unfiltered liquid side during a filtration process from a surface of the membrane medium, or promotes drop formation of the dispersed phase exiting from a membrane surface on the side facing the coherent phase during an emulsification process. The invention further relates to uses of the device.

Filtration and emulsification device

A system for packaging a low acid liquid is provided herein. The system includes feeding unit configured to feed the low acid liquid into a filtration unit. The filtration unit is configured to filter the low acid liquid by using a number of pores provided on a micro sieve membrane. Further, the filtered low acid liquid is provided to an aseptic buffer unit configured to fill the aseptic filtered low acid liquid into packaging containers. The system further includes an automatic cleaning in place unit configured to automatically clean the feeding unit, the filtration unit and the aseptic buffer unit by decontamination using a decontaminating material.

System and method for aseptic and sterile packaging of low acid liquids

A micro well plate is described for capturing and distributing single cells in individual wells is described, wherein at least one individual well is provided with a bottom plate having at least one pore to pass sample liquid, such that if one object or cell of interest is collected on the bottom plate of the well, the sample flow rate through that particular well is significantly reduced, minimizing the possibility that multiple cells or objects of interest entering the same well. The presented invention is particularly suited for obtaining single cells and/or microorganisms suspended in fluid samples for subsequent detailed interrogation.

Microsieve diagnostic device in the isolation and analysis of single cells

A device can be used to retain circulating tumor cells (CTCs). The device can include a cross-flow module with a retentate channel and a permeate channel. A filter in the cross-flow module can separate the retentate channel from the permeate channel. The filter can be constructed such that CTCs are retained in the retentate channel while other cells can pass through the filter into the permeate channel. A recirculation channel can direct a flow from an outlet of the retentate channel back to an inlet of the retentate channel to thereby concentrate CTCs in the retentate flow.

Extracorporeal fluidic device for collecting circulating tumor cells and method of use thereof

Nozzle device and nozzle for atomisation and/or filtration as well as methods for using the same. The present invention relates to a nozzle and nozzle device for atomisation, in particular a micro-machined reinforced nozzle plate, that may produce small liquid droplets in air (spray) or into a liquid (emulsion) with a narrow droplet size distribution and to make small air bubbles into a liquid (foam) and to methods of making the same. The invention is further related to a nozzle part for filtration as well as means and methods to facilitate atomisation and filtration.

Nozzle device and nozzle for atomisation and/or filtration and methods for using the same

An atomizing device, includes an atomizing body () with an inlet () for receiving a fluid under increased pressure, and with at least one set of outflow ports () for allowing the fluid to escape on a delivery side with forming of a vapor. Imaginary central axes of the outflow ports directed in a flow direction herein enclose a mutual angle (&#x3b1;) in order to intersect each other at an intersection (S). The atomizing body includes a roof () and a bottom (which extend over at least a first distance (d) beyond the set of outflow ports () and bound a vaporizing space () on either side. The intersection (S) of the imaginary central axes of the outflow ports lies at a second distance (d) from the set of outflow ports, wherein the second distance (d) is greater than the first distance (d) and extends beyond the vaporizing space.

Growing community of inventors

Hengelo, Netherlands

Cornelis Johannes Maria Van Rijn