Avi Biopharma, Inc.

Cornelis A Rijnbrand

Patrick L Iversen

Dwight D Weller

David A Stein

The invention provides antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Picornaviridae family and in the treatment of a viral infection. The compounds are particularly useful in the treatment ofand/orinfection in a mammal. The antisense antiviral compounds are substantially uncharged, including partially positively charged, morpholino oligonucleotides have a sequence of 12-40 subunits, including at least 12 subunits having a targeting sequence that is complementary to a region associated with viral RNA sequences within a 32 nucleotide region of the viral 5' untranslated region identified by SEQ ID NO:4.

Growing community of inventors

Poway, CA, United States of America

Cornelis A Rijnbrand