Actelion Pharmaceuticals Ltd

Cornelia Zumbrunn Acklin

Christian N Hubschwerlen

Georg Rueedi

Christoph Boss

Thierry Sifferlen

Hamed Aissaoui

Daniel Bur

Jean-Philippe Surivet

Christian Hubschwerlen

Markus Gude

Ralf Koberstein

Daniel Ritz

Rueedi Georg

Verena Kaegi-egger

The invention relates to antibacterial compounds of formula I wherein one or two of U, V, W, and X represent N, the rest represent CH or, in the case of X, may also represent CRwherein Ris fluorine; Rrepresents alkoxy, halogen or cyano; Rrepresents H, CHOH, CHN, CHNH, alkylcarbonylaminomethyl or triazol-1-ylmethyl; Rrepresents H, or, when n is 1, Rmay also represent OH, NH, NHCORor triazol-1-yl; A represents CR; K represents O, NH, OCH, NHCO, NHCH, CHNH, CHCH, CH&#x2550;CH, CHOHCHOH or CHR; Rrepresents H or together with Rforms a bond, or also Rcan represent OH when K is not O, NH, OCHor NHCO; Rrepresents OH or together with Rforms a bond; Rrepresents alkyl; m is 0 or 1 and n is 0 or 1; and G is as defined in the description;and to salts of such compounds.

5-aminocyclylmethyl-oxazolidin-2-one derivatives

The invention relates to antibacterial compounds of formula I wherein

2-oxo-oxazolidin-3,5-diyl antibiotic derivatives

The invention relates to antibacterial compounds of formula I wherein G and K are as defined in the description; and salts of such compounds.

3,7-disubstituted octahydro-2H-pyrido[4,3-E][1,3]oxazin-2-one antibiotics

The invention relates to antibacterial compounds of formula (I), wherein Ris H, halogen, (C-C)alkyl or (C-C)alkoxy; Ris H, halogen, (C-C)alkyl, (C-C)alkoxy or pyrrolidin-1-yl; Ris H, halogen, (C-C)alkyl, (C-C)alkoxy, vinyl or 2-methoxycarbonyvinyl or Rand Rtogether with the two carbon atoms which bear them form a phenyl ring; Ris H, halogen, (C-C)alkyl or (C-C)alkoxy; and Ris H, (C-C)alkyl or cyclopropyl, or Rand Rform together a &#x2014;CHCHCH&#x2014; group; A is the divalent group &#x2014;CH&#x2014;, &#x2014;CHCH&#x2014;, #&#x2014;CH(OH)CH&#x2014;*, #&#x2014;CHN(R)&#x2014;* and &#x2014;CHNHCH&#x2014;, wherein # indicates the point of attachment to the optionally substituted (quinazoline-2,4-dione-3-yl)methyl residue and * represents the point of attachment to the substituted (oxazolidinon-4-yl)methyl residue; Ris H or acetyl; Y is CH or N; and Q is O or S; and salts of such compounds.

Quinazoline-2,4-dione derivatives

The invention relates to antibacterial compounds of formula I 

2-hydroxyethyl-1H-quinolin-2-one derivatives and their azaisosteric analogues with antibacterial activity

The invention relates to novel sulfonamide compounds of the formula (I) and their use as orexin receptor antagonists.

N-glycinsulfonamide derivatives and uses as orexin receptor antagonists

The invention relates to antibiotic cyclohexyl or piperidinyl carboximide derivatives of formula (I) wherein

Cyclohexyl or piperidinyl carboxamide antibiotic derivatives

The invention relates to antibiotic ethanol or 1,2-ethanediol cyclohexyl derivatives of formula (I) wherein R1 represents (C-C)alkoxy; one or two of U, V, W and X represents) N and the remaining represent each independently CH or, in the case of V or X, may also represent CR; Rrepresents halogen; Rrepresents H or OH; A represents CH, CO, CHCH&#x2550;CH or COCH&#x2550;CH; D represents a phenyl group optionally substituted one or two times by halogen atoms, or D represents a group of the formula (II) in which Q is oxygen or sulphur; and to salts of these derivatives of formula (I). 

Growing community of inventors

Basel, Switzerland

Cornelia Zumbrunn Acklin