Universiteit Gent

Bangor University

Cornelia Theunissen

Mark Stephen Baird

Johan Adriaan Marc Grooten

Gani Koza

Seppe Vander Beken

Juma' A Raheem Najeem Al-Dulayymi

A compound of formula (I) for use as an adjuvant in vaccination; wherein R is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 50 carbon atoms; Ris an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 40 carbon atoms; each of R, Rand Ris independently selected from an optionally-substituted alkylene, alkenylene, alkynylene, arylene, arylalkylene or alkylarylene moiety having from 1 to 40 carbon atoms; each of X, Y and Z is independently selected from an optionally-substituted alkylene, alkenylene, alkynylene, arylene, alkylarylene or cycloalkylene, ketone, ester, amide, imide, imine, thioether, ether, thioester, thioketone; and P is selected from hydrogen, an alkyl group, a sugar residue, or a metal, phosphonium or ammonium species; wherein at least one of X, Y and Z includes a moiety selected from cyclopropyl, C=A, C-AH and C&#x2014;OR; wherein Ris alkyl or haloalkyl, and A is S, O or NR, wherein Rmaybe H or 20 alkyl. 

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Cornelia Theunissen