Dyadic International (usa), Inc.

Dyadic International, Inc.

Cornelia Marie Johanna Van Zeijl

Peter Jan Punt

Richard Paul Burlingame

Arkady Panteleimonovich Sinitsyn

Christine Marie Pynnonen

Philip Terry Olson

Jean Christophe Bousson

Martine Parriche

Mark Aaron Emalfarb

Mark Aaron Emalfrab

A novel transformation system in the field of filamentous fungal hosts for expressing and secreting heterologous proteins or polypeptides is described. The invention also covers a process for producing large amounts of polypeptide or protein in an economical manner. The system comprises a transformed or transfected fungal strain of the genus, more particularly ofand mutants or derivatives thereof. It also covers transformants containingcoding sequences, as well expression-regulating sequences ofgenes. Also provided are novel fungal enzymes and their encoding sequences and expression-regulating sequences.

Transformation system in the field of filamentous fungal hosts

A novel transformation system in the field of filamentous fungal hosts for expressing and secreting heterologous proteins or polypeptides is described. The invention also covers a process for producing large amounts of polypeptide or protein in an economical manner. The system comprises a transformed or transfected fungal strain of the genus Chrysosporium, more particularly of and mutants or derivatives thereof. It also covers transformants containing Chrysosporium coding sequences, as well expression-regulating sequences of Chrysosporium genes. Also provided are novel fungal enzymes and their encoding sequences and expression-regulating sequences.

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Vleuten-de-Meern, Netherlands

Cornelia Marie Johanna Van Zeijl