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Cornelia Dreef-Tromp

Maurice Petitou

Jean Marc Herbert

Philippe Duchaussoy

Constant Van Boeckel

Pierre Alexandre Driguez

Johannes Basten

Peter Grootenhuis

A synthetic polysaccharide including an antithrombin III binding domain consisting of a concatenation of five monosaccharides supporting a total of two carboxylic acid functions and at least four sulpho groups, said domain being directly bound at the non-reducing end by a thrombin binding domain including a concatenation of 10-25 monosaccharide units selected from hexoses, pentoses or deoxy sugars of which all the hydroxyl groups are etherified by a C alkyl group or esterified in the form of sulpho groups, as well as salts and particularly pharmaceutically acceptable salts thereof, are disclosed.

Synthetic polysaccharides, preparation method therefor and pharmaceutical compositions containing same

Novel synthetic polysaccharides for use in the treatment of pathologies associated with a coagulation dysfunction.

Synthetic polysaccharides, their method of production and pharmaceutical compositions containing same

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Wijchen, Netherlands

Cornelia Dreef-Tromp