Agenus Inc.

Memorial Sloan Kettering Cancer Center

Ludwig Institute for Cancer Research Limited

Novartis Ag

Mink Therapeutics, Inc.

Cornelia Anne Mundt

Marc A Van Dijk

Nicholas Stuart Wilson

David Adam Savitsky

Gerd J Ritter

Taha Merghoub

Jedd David Wolchok

David Schaer

Mark Arthur Findeis

Dennis John Underwood

Jean-Marie Cuillerot

Igor Proscurshim

Olga Shebanova

Roberta Zappasodi

Shawn Michael Jennings

Olga Ignatovich

Yanping Xiao

Benjamin Maxime Morin

Dhan Sidhartha Chand

Rikke Baek Holmgaard

Rikke Bæk Holmgaard

Volker Seibert

Mark A Exley

Benjamin Jacob Wolf

Arthur Andrew Hurwitz

Sébastien Lalevée

Joseph Anthony D'Alessio

Tamás Schweighoffer

Reed Masakayan

Daniel Leventhal

Claudia Judith Klinter

Richard Vaughan Newcombe

Katharina Winkelbach

The instant disclosure provides antibodies that specifically bind to CTLA-4 (e.g., human CTLA-4) and antagonize CTLA-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Anti-CTLA-4 antibodies and methods of use thereof

The instant disclosure provides antibodies that specifically bind to LAG-3 (e.g., human LAG-3) and antagonize LAG-3 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Anti-LAG-3 antibodies and methods of use thereof

Disclosed herein are antibodies, antigen binding fragments thereof, and antibody drug conjugates thereof that bind human CD48. Also disclosed are pharmaceutical compositions comprising the antibodies, antigen binding fragments thereof, and antibody drug conjugates thereof; and methods of making and using such pharmaceutical compositions for treating cancer in a patient in need of treatment.

Anti-CD48 antibodies, antibody drug conjugates, and uses thereof

Anti-lag-3 antibodies and methods of use thereof

Provided are antibodies that specifically bind to CTLA-4 and/or PD-1 and antagonize CTLA-4 and/or PD-1 function. Also provided are pharmaceutical compositions and kits comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies either alone or in combination.

Antibodies and methods of use thereof

Provided are TCRs (e.g., TCRs that bind to NY-ESO-1), cells and pharmaceutical compositions comprising these TCRs, nucleic acids encoding these TCRs, expression vectors and host cells for making these TCRs, and methods of treating a subject using these TCRs.

T cell receptors that bind to NY-ESO-1 and methods of use thereof

The instant disclosure provides antibodies that specifically bind to human PD-1 and antagonize PD-1 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Anti-PD-1 antibodies and methods of use thereof

The instant disclosure provides antibodies that specifically bind to human CTLA-4 and antagonize CTLA-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

The instant disclosure provides antibodies that specifically bind to CD137 (e.g., human CD137) and increases CD137 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Anti-CD137 antibodies and methods of use thereof

Growing community of inventors

Lörrach, Germany

Cornelia Anne Mundt