University of California

University of Central Florida Research Foundation Inc

Memorial Sloan Kettering Cancer Center

The Broad Institute, Inc.

Columbia University

Corinne N Foley

Derek Shieh Tan

Sivaraman Dandapani

Debopam Chakrabarti

Alyssa Verano

Gustavo Moura-Letts

Bracken Roberts

Rahul Edwankar

Stephen Ho

James H McKerrow

James L Leighton

James McKerrow

The present disclosure provides compounds of Formula (I'), Formula (II), and Formula (III). The compounds described herein may useful in treating and/or preventing protozoan infections in a subject in need thereof, treating and/or preventing trypanosomal infections (e.g.,() orinfections) and/or plasmodial infections in a subject in need thereof, treating and/or preventing diseases in a subject in need thereof (e.g., Chagas disease, malaria, and/or sleeping sickness), and may be useful in treating and/or preventing infectious diseases in a subject in need thereof. Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including a compound described herein.

Anti-parasitic compounds and uses thereof

The present disclosure provides compounds of Formula (I'), Formula (II), and Formula (III). The compounds described herein may useful in treating and/or preventing protozoan infections in a subject in need thereof, treating and/or preventing trypanosomal infections (e.g.,() orinfections) and/or plasmodial infections in a subject in need thereof, treating and/or preventing diseases in a subject in need thereof (e.g., Chagas disease, malaria, and/or sleeping sickness), and may be useful in treating and/or preventing infectious diseases in a subject in need thereof. Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including a compound described herein. 

Epothilone B and dictyostatin analogs, their preparation and use

Growing community of inventors

New York, NY, United States of America

Corinne N Foley