Sanofi

Corinne Leroy

Xavier Bon

Philippe Vayron

Julia Mateos-Caro

Christine Biencourt

The disclosure relates to a process for preparing 5-aminobenzoylbenzofuran derivatives of formula I: in which Rand Rare as defined in the disclosure; by reduction of a 5-nitrobenzofuran derivative of formula II: using a hydrogen transfer agent, in the presence of palladium-on-charcoal as catalyst and in an ether or an ether mixture as solvent.

Process for preparing aminobenzoylbenzofuran derivatives

This disclosure relates to a process for preparing 5-aminobenzofuran derivatives of general formula (I): in which Rand Rare as defined in the description,by treating a 5-N-alkylamidobenzofuran derivative of general formula (II): in which R, R, and Rare as defined in the description, with a strong acid, so as to form an acid addition salt of the compound of formula (I), which salt is itself treated, if necessary, with a basic agent so as to form this compound of formula (I) in free base form.

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Paris, France

Corinne Leroy