Nordion (canada) Inc.

Nordion Inc.

Corinne Bensimon

A Dean Sherry

Garry E Kiefer

Zoltan Kovacs

Cara L Ferreira

Lihui Wei

Xuxu Yan

Terrence David Ruddy

Gyula Tirsco

Zoltan Kovaks

The present application discloses a compound of formula (I) or (II): 

Radiolabelled rotenone derivatives and their use in SPECT imaging

A bifunctional polyazamacrocyclic chelating agent of the formula (I): wherein: and the variables A, L, Q, Q, X, Y, Z, Z, m, n and r are as defined in the description of the present application. Also described is a complex of the above chelating agent to an ion of a metal ion, such as an ion ofY,In orLu; a conjugate of the complex covalently attached to a biological carrier; and a pharmaceutical composition containing the conjugate. A method of therapeutic treatment of a mammal involving administration of the pharmaceutical composition is also described.

Bifunctional polyazamacrocyclic chelating agents

A bifunctional polyazamacrocyclic chelating agent of the formula (I): wherein: and the variables A, L, Q, Q, X, Y, Z, Z, m, n and r are as defined in the description of the present application. Also described is a complex of the above chelating agent to an ion of a metal ion, such as an ion ofY,Li orLu; a conjugate of the complex covalently attached to a biological carrier; and a pharmaceutical composition containing the conjugate. A method of therapeutic treatment of a mammal involving administration of the pharmaceutical composition is also described.

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Nepean, Canada

Corinne Bensimon