Gruenenthal Gmbh

Grunenthal Gmbh

Leiden University

Corinna Sundermann

Bernd Sundermann

Hagen-Heinrich Hennies

Werner Guenter Englberger

Stefan Oberboersch

Helmut Buschmann

Edward Bijsterveld

Matthias Gerlach

Beatrix Merla

Michael Haurand

Michael Przewosny

Babette-Yvonne Koegel

Ruth Jostock

Claudia Katharina Puetz

Stefan Ober-Boersch

Klaus Schiene

Thomas Christoph

Melanie Reich

Robert Frank

Sven Kühnert

Utz-Peter Jagusch

Sven Kuehnert

Saskia Zemolka

Boris Chizh

Dagmar Kaulartz

Heinz Uragg

Adriaan Pieter Ijzerman

Thomas Tzschentke

Babette-Yvonne Kögel

Stefan Oberbörsch

Reynier Tromp

Jörg Holenz

HagenHeinrich Hennies

Jacobien Von Frijtag Drabbe Kuenzel

Barbara Heller

Edward Dr Bijsterveld

Bernd Dr Sundermann

The present invention relates to substituted 1-oxa-3,8-diazaspiro[4.5]-decan-2-one compounds, to methods for the production thereof, to medicaments containing these compounds and to the use of these compounds for producing medicaments.

Substituted 1-oxa-3,8-diazaspiro[4.5]-decan-2-one-compounds and the use thereof for producing drugs

Novel cyclohexyl-1,4-diamine compounds corresponding to formula I, processes for the production thereof, pharmaceutical compositions containing these compounds, methods of producing pharmaceutical compositions including these compounds and related methods of treating or inhibiting certain diseases or conditions.

Heteroaryl substituted cyclohexyl-1,4-diamine compounds

Cyclohexyl-1, 4-diamine compounds

The present invention relates to substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compound corresponding to formula I, methods for producing them, to medicaments containing these compounds, the use of these compounds for producing medicaments and related treatment methods 

Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments

1,3-disubstituted 4-methyl-1H-pyrrole-2-carboxamides corresponding to formula I methods for their production, pharmaceutical compositions containing them, and the use thereof for noradrenalin receptor regulation, particularly for inhibiting noradrenalin reuptake, and/or for 5-HT receptor regulation, particularly for inhibiting 5-hydroxy tryptophan reuptake, and/or for opioid receptor regulation and/or for batrachotoxin (BTX) receptor regulation and/or for treating or inhibiting pain and other conditions.

1,3-disubstituted 4-methyl-1H-pyrrole-2-carboxamides and their use in medicaments

Novel 1,4,8-triazaspiro[4,5]decan-2-one compounds corresponding to formula I processes for the preparation thereof, related methods of treatment and pharmaceutical formulations containing such compounds.

Substituted 1,4,8-triazaspiro [4,5]decan-2-one compounds

Substituted 5-aminomethyl-1H-pyrrole-2-carboxylic acid amides, a process for the production thereof, pharmaceutical preparations containing these compounds and the use of these compounds in pharmaceutical preparations for treatment or inhibition of withdrawal symptoms, memory disorders, neurodegenerative diseases, epilepsy, cardiovascular disorders, water retention, intestinal motility disorders, urinary incontinence, anorexia, tinnitus, pruritus, depression, sexual dysfunction, airways diseases, food intake disorders, or type II (non-insulin-dependent) diabetes, or for anxiolysis, diuresis, suppression of the urinary reflex, reducing the addictive potential of opioids, modulating locomotor activity, influencing the cardiovascular system, or regulating electrolyte balance.

Substituted 5-aminomethy1-1H-pyrrole-2-carboxylic acid amides

Substituted 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridin-2-ylamine compounds corresponding to formula I, methods for the preparation thereof, pharmaceutical compositions containing said compounds, the use of said compounds for preparing pharmaceutical compositions and related treatment methods. 

Substituted 5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-ylamine compounds and their use for producing drugs

Novel cyclohexyl-1,4-diamine compounds corresponding to formula I processes for preparing such compounds, pharmaceutical formulations comprising these compounds, methods of making such pharmaceutical formulations and the related methods of treating or inhibiting certain conditions or disorders.

Cyclohexyl-1,4-diamine compounds

Pharmaceutical preparations containing substituted 2,5-diaminomethyl-1H-pyrrole compounds corresponding to formula I, and the use of these compounds for the production of pharmaceutical preparations and in related treatment methods.

Pharmaceutical preparations containing substituted 2,5-diaminomethyl-1H-pyrroles

Sulfonylguanidine compounds corresponding to the tautomeric formulas I and Ia, a method for producing them, pharmaceutical compositions containing them, and methods of using them to prepare medicaments and for treating various medical conditions. The sulfonylguanidine compounds have an affinity for the gabapentin binding site and can be used to treat conditions such as pain, epilepsy, migraine and others.

Sulfonylguanidine compounds and pharmaceutical uses thereof

Substituted 5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-2-yl and 5,6,7,8-tetrahydro-quinazolin-2-yl compounds, corresponding to formula I processes for the production thereof, pharmaceutical preparations containing these compounds the use thereof for the production of pharmaceutical preparations and related method of treating or inhibiting certain disorders or conditions, including pain.

Substituted 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2-yl compounds and 5,6,7,8-tetrahydroquinazoline-2-yl compounds

Substituted imidazo[1,2-a]pyridine compounds, a process for the production thereof, pharmaceutical preparations containing such compounds and methods of using such substituted imidazo[1,2-a]pyridine compounds to treat and/or inhibit various diseases or pathological conditions.

Substituted imidazo[1,2-a]pyridine compounds and pharmaceutical preparations containing substituted imidazo[1,2-a]pyridine compounds

Substituted 1,4,8-triazaspiro[4,5]decan-2-one compounds

Novel cyclohexyl-1,4-diamine compounds corresponding to formula I: methods for their production, pharmaceutical formulations containing these compounds, methods of producing such pharmaceutical formulations and related methods of treating or inhibiting certain diseases or conditions.

Oxo-substituted cyclohexyl-1,4-diamine compounds

Growing community of inventors

Aachen, Germany

Corinna Sundermann