Boehringer Ingelheim International Gmbh

Corinna Schoelch

Elke Langkopf

Holger Wagner

Annette Schuler-Metz

Alexander Pautsch

Ruediger Streicher

Matthias Eckhardt

Joerg Kley

Juergen Mack

Norbert Redemann

Bradford S Hamilton

Rüdiger Streicher

The invention relates to cyclopentanecarboxamide derivatives of formula 1, to their use as Fatty Acid Synthase inhibitors, to methods for their therapeutic use and to pharmaceutical compositions containing them, wherein R, R, R, LO, W, AR, n are as defined in claim. 

Cyclopentanecarboxamide derivatives, medicaments containing such compounds and their use

The present invention relates to substituted arylsulphonylaminomethyl-phosphonic acid derivatives of general formula wherein R, X, Y and Z are defined as in claim, the tautomers, enantiomers, diastereomers, mixtures thereof and salts thereof which have valuable pharmacological properties, particularly the suppression of the interaction of glycogen phosphorylase a with the Gsubunit of glycogen-associated protein phosphatase 1 (PP1), and their use as pharmaceutical compositions.

Substituted arylsulfonylaminomethylphosphonic acid derivatives, their preparation and their use in the treatment of type I and II diabetes mellitus

The present invention relates to substituted arylsulphonylglycines of general formula (I) wherein R, X, Y and Z are defined as in claim, the tautomers, enantiomers, diastereomers, mixtures thereof and salts thereof, which have valuable pharmacological properties, particularly the suppression of the interaction of glycogen phosphorylase a with the GL subunit of glycogen-associated protein phosphatase 1 (PP1), and their use as pharmaceutical compositions. 

Substituted arylsulphonylglycines, the preparation thereof and the use thereof as pharmaceutical compositions

The invention relates to substituted arylsulphonylaminomethylphosphonic acid derivatives of general formula (I) wherein the groups Rto R, A and Z are defined as mentioned in the specification and claims, which are suitable for preparing a medicament for the treatment of metabolic disorders, particularly type 1 or type 2 diabetes mellitus. 

Arylsulfonylaminomethylphosphonic acid derivatives, the preparation thereof and the use thereof as pharmaceutical compositions

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Mittelbiberach, Germany

Corinna Schoelch