Lonza Inc.

Corinna Rebnegger

Diethard Mattanovich

Brigitte Gasser

Mirelle Citiali Flores Villegas

Mirelle Citlali Flores Villegas

A recombinant host cell comprising an endogenous gene encoding a FLO8 protein comprising the amino acid sequence identified as SEQ ID NO:1 or a homologue thereof, which host cell is engineered by one or more genetic modifications to reduce expression of said gene compared to the host cell prior to said one or more genetic modifications, and which host cell comprises a heterologous expression cassette comprising a gene of interest (GO!) under the control of an expression cassette promoter (ECP) which ECP is repressible by a non-methanol carbon source, and a method of producing a protein of interest using said recombinant host cell.

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Vienna, Austria

Corinna Rebnegger