Gruenenthal Gmbh

Grunenthal Gmbh

Corinna Maul

Matthias Gerlach

Bernd Sundermann

Utz-Peter Jagusch

Werner Guenter Englberger

Helmut Heinrich Buschmann

Hagen-Heinrich Hennies

Helmut Buschmann

Michael Przewosny

Boris Chizh

Heinz Uragg

Joerg Holenz

Michael Haurand

Tieno Germann

Petra Bloms-Funke

Elke Reissmueller

Guenter Werner Englberger

Heinrich Helmut Buschmann

Babette-Yvonne Koegel

Johannes Schneider

Michael Finkam

Hagen-Henrich Hennies

Michael Haubrand

Claudia Katharina Pütz

Substituted 1-oxa-2,8-diaza-spiro[4,5]dec-2-ene compounds and processes for their production, the use thereof for producing pharmaceutical compositions, pharmaceutical compositions containing these compounds and methods of treatment using these compounds.

Substituted 1-oxa-2,8-diaza-spiro [4,5] dec-2-ene derivatives and related treatment methods

Substituted 1-oxa-2,8-diaza-spiro[4,5]dec-2-ene derivatives and related treatment methods

Pharmaceutical formulations comprising N,N'disubstituted piperazine compounds and related methods of treatment using these formulations.

Pharmaceutical formulations comprising N,N'-disubstituted piperazine compounds

Substituted 1,5-diaminopentan-3-ol compounds and methods of making the same. Pharmaceutical compositions containing these compounds and methods of treatment using these pharmaceutical compositions.

1, 5-diaminopentan-3-ol compounds and related treatment methods

Pharmaceutical compositions containing substituted aminoalcohols, the use of preparations containing substituted aminoalcohols for treatment of conditions such as pain, emesis, neurotropic conditions, cardiovascular diseases, urinary incontinence, diarrhea, pruritus, alcohol or drug dependency, inflammation, depression, decreased vigilance, or depressed libido, as well as 2-(aminomethyl)cycloalkane-1-ol compounds and a process for their preparation.

Pharmaceutical preparations comprising substituted beta-aminoalcohols

Substituted C-cyclohexylmethylamine derivatives, methods for the production thereof, pharmaceuticals containing said compounds, the use of substituted C-cyclohexylmethylamine derivatives for producing pharmaceuticals, and method of pain treatment using the pharmaceuticals.

Substituted C-cyclohexylmethylamine derivatives

Substituted-dihydropyrido[1,2-a]pyrimidines of formula I and processes for the production thereof Also disclosed are substance libraries and pharmaceutical compositions containing the compound, and methods of treatment for pain, urinary incontinence, pruritus, tinnitus and/or diarrhoea using the pharmaceutical composition.

Substituted 3,4-dihydropyrido[1,2-a]pyrimidines

Substituted 3,4-dihydro-pyrimido[1,2a]pyrimidines and 3,4-dihydro-pyrazino[1,2a]pyrimidines of general formula I, the invention also relates to a method for the production thereof, substance libraries containing these compounds, medicaments which contain these compounds in the production of medicaments for treating pain, urinary incontinence, itching, tinnitus aurium and/or diarrhea and to pharmaceutical compositions containing these compounds.

Substituted 3,4-dihydro-pyrimido[1,2a]pyrimidines and 3,4-dihydro-pyrazino[1,2a]pyrimidines, and methods for their preparation and use

The invention relates to substituted 1 and 2 naphthol Mannich bases, a method for the production thereof, medicaments containing said compounds and the use of said compounds in the production of medicaments.

Substituted 1 and 2-naphthol Mannich bases

Substituted 5,6,6a,11b-tetrahydro-7-oxa-5-aza-benzo[c]fluorene-6-carboxylic acid compounds, and processes for the production thereof, pharmaceutical compositions containing these compounds and the use thereof in treatment methods and for the production of pharmaceutical preparations for specific indications, in particular for the treatment of pain.

Substituted 5,6,6a, 11b-tetrahydro-7-oxa-5-aza-benzo[c]fluorene-6-carboxylic acid compounds as NMDA-antagonists

The present invention relates to substituted indole Mannich bases, processes of preparing substituted indole Mannich base, a medicament containing the same, and a pharmaceutical composition containing the same.

Substituted indole Mannich bases

The invention relates to substituted pyrrole Mannich bases of general formula (I), wherein R=H, a C-alkyl-, aryl, a heteroaryl- or an aryl, heteroaryl-, CN, Br&#x2014;, Cl or OH radical bound by a Calkylene group, R=CH(R)N(R)(R), R3, R3', R3&#x2033; identically or individually represent H, F, Cl, Br, CF, CN, NO, SONH, NHR, SR, OR, CO(OR), CHCO(OR), COR, a C-alkyl-, aryl-, heteroaryl-aryl radical or a heteroalkyl radical bound by a Calkylene group, R=an unsubstituted phenyl radical or a phenyl radical substituted at least with Calkyl, C-alkoxy-, halogen-, a method for the production of the above-mentioned compounds, medicaments containing said compounds, and the use of said compounds in the production of medicaments. Said active ingredients are particularly suitable for pain therapy, and for treating inflammatory and allergic reactions, drug or alcohol abuse, diarrhoea, gastritis, ulcers, cardiovascular diseases, urinary incontinence, depressions, states of shock, migranes, narcolepsy, overweight, asthma, glaucoma, hyperkinetic syndrome, lack of drive, bulimia, anorexia, catalepsia, anxiolysis increasing vigilance and/or increasing libido.

Substituted pyrrole mannich bases to combat pain and allergic reactions

Substituted 1-aminobutane-3-ol compounds, methods for producing them, pharmaceutical compounds containing them, and the use of substituted 1-aminobutane-3-ol compounds for producing pharmaceutical compounds.

Substituted 1-aminobutan-3-ol compounds

A novel bicyclic imidazo-5-yl-amine derivative of Formula I,wherein X denotes CR, N or S, and Y in the case where X denotes S, denotes CRor N and in all other cases denotes N, and methods for preparation thereof are disclosed. Also disclosed are methods for treating pain using the compound of Formula I, and pharmaceutical compositions comprising the compound of Formula I.

Bicyclic imidazo-5-yl-amine derivatives

Bicyclic imidazo-3-yl-amine derivatives substituted on the 6-membered ring, and pharmaceutical compositions containing these compounds, useful, inter alia, as analgesics.

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Aachen, Germany

Corinna Maul