The Charles Stark Draper Laboratory, Inc.

Corin Williams

Jesse M Carr

Joseph L Charest

Jonathan Robert Coppeta

Stephanie Lynne Golmon

Brett C Isenberg

Daniel F King

Else M Vedula

Ernest Kim Soonho

Morgan Pilkenton

Elizabeth Ellen Marr

Patrick Davis

The systems and methods of the present disclosure provide highly deformable porous membrane culture systems and actuation methods for studying the effects of biomedical stretch on cultured tissue. A well plate can include a well having a first opening configured to receive an insert coupled to a deformable membrane. The well plate can include a gasket positioned within the well and configured to create a seal between the insert and the well when the insert is positioned in the well. The well plate can include a chamber defined beneath the well, the chamber configured to receive fluid media and to expose the fluid media to a surface of the deformable membrane when the insert is positioned in the well. The well plate can include an actuator configured to stretch the deformable membrane by a target amount of strain.

Highly deformable porous membrane culture system and actuation methods for studying the effects of biomechanical stretch on cultured tissue

According to various aspects and embodiments, a growth adaptive expandable stent is provided. The expandable stent includes a stent structure having a cylindrical shape that is self-expanding in a radial direction and includes a plurality of cylindrical rings disposed along a longitudinal axis of the stent structure. The stent structure is configured to exert a continuous outward radial force over time when implanted such that a diameter of the stent structure expands from a first value to a second value that is at least about 1.5 times the first value.

Growth adaptive expandable stent

According to various aspects and embodiments, a prosthetic valve assembly for controlling fluid flow in an annulus is provided. The prosthetic valve assembly includes a suture ring formed from two or more segments, where each segment is configured to attach to the annulus, and a leaflet subassembly that attaches to an inner portion of at least one segment of the suture ring. The leaflet subassembly includes at least one leaflet configured for controlling a flow of fluid through the prosthetic valve assembly.

Segmented, growth-accommodating, artificial valve

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Framingham, MA, United States of America

Corin Williams