Penumbra, Inc.

Corey Teigen

Scott Teigen

Cheng Yong Timothy Thio

Lincoln Herbert Davidson

Robyn Shaffer

Steve Loisel

Nitika S Chellappa

Akhilesh R R Yeluru

Robert D Schultz

Annam K Quraishi

Melissa E R Jones

Justin M Olshavsky

Aurko J Shaw

Evan T Koretsky

Michael E Salamy

Matthew W L Sprinkel

Bridget C Vaughan

Anderson S Lee

An aspiration thrombectomy system for use with an aspiration catheter, connection tubing to place a vacuum source and the aspiration catheter in fluid communication, controllable valves to control a level of negative pressure provided by the vacuum source, ultrasonic sensors to detect ultrasonic energy in the aspiration catheter or the connection tubing, and an automated controller to generate, via the controllable valves, while the system is operated in a first operational state, a pressure wave in the aspiration catheter or the connection tubing, detect, via the ultrasonic sensors, ultrasonic energy in the aspiration catheter or the connection tubing based on ultrasonic energy originating from the ultrasonic sensors, determine, based at least in part on the generated pressure wave and the detected ultrasonic energy, a system state in the aspiration catheter or the connecting tubing, and operate, based on the determined system state, the system in a second operational state.

Aspiration thrombectomy system and methods for dynamic system state detection

An aspiration thrombectomy system for use with a vacuum source and an aspiration catheter includes an aspiration catheter, connection tubing configured to act as a common conduit for fluid communication between the aspiration catheter and a vacuum source, controllable valves operable to selectively open and close to control fluid flow, pressure sensors associated with the aspiration catheter or the connection tubing, and an automatic controller configured to operate the valves in a first operational state to generate fluid pressure changes, detect pressure levels in the system, wherein changes in the detected pressure levels are correlated with the generated fluid pressure changes, determine system states based on system state scores determined based on the detected pressure levels, the system state scores indicating a measure of occlusion in the aspiration catheter or the connection tubing, and operate the valves in a second operational state based on the determined system states.

Venous infusion catheter assemblies and methods of use are described herein. A catheter assembly may comprise an elongated body having a proximal end and a distal end, with an expandable occlusion element disposed on the elongated catheter body. A catheter may include a first infusion lumen extending to a proximal infusion port positioned on the catheter body proximally of the occlusion element and a second infusion lumen extending to a distal infusion port. Some embodiments may use a suction lumen extending to at least one suction port. When the catheter is introduced into vasculature of a patient, the suction port may be positioned in the patient's superior vena cava or right atrium to draw blood, the distal infusion port is positioned to direct normothermic or hyperthermic fluid toward the patient's heart, and the proximal infusion port is positioned to create a flow of hypothermic fluid in the patient's cerebral vasculature.

Infusion catheter and methods of use

An aspiration thrombectomy system for use with a vacuum source and an aspiration catheter includes a connection tubing configured to selectively connect the aspiration catheter to the vacuum source via a controllable vacuum valve. A distal pressures sensor is configured to detect pressure at the distal end within the connection tubing. An automatic controller may operate the vacuum valve to generate fluid pressure change in the connection tubing, and detect pressure profiles in the connection tubing correlated with the generated pressure changes via the distal pressure sensor. The automatic controller may determine one or more system states in the aspiration catheter or connection tubing based on the detected pressure profiles, and may operate the vacuum valve based on the determination of system state.

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Rosholt, SD, United States of America

Corey Teigen