Cytokinetics, Inc.

Mj Research, Inc.

Corey E Nislow

Christophe Beraud

Roman Sakowicz

Kee Wong

John R Linton

Peter B Vander Horn

Michael J Finney

Bruce R Turner

Daniel E Sullivan

Sean Rubin

Charles P Andre

Alexis Vira

William D Bowers

The invention provides isolated nucleic acid and amino acid sequences of profilin, methods of screening for profilin modulators using biologically active profilin, and kits for screening for profilin modulators.

Aspergillus fumigatus profilin

The invention provides an electrophoresis cassette to cast electrophoresis gels and to separate and analyze molecular components by electrophoresis. The electrophoresis cassette comprises a top plate assembly, a spacer and a bottom plate. The top plate assembly is seated to the bottom plate with the spacer there between to define a thickness of the electrophoresis cassette and to seal an outer perimeter of the assembly. The top plate assembly includes a cathode reservoir connected to a first terminal end of a central plate, and an anode reservoir connected to a second terminal end of the central plate. When the electrophoresis cassette is assembled, the cathode and anode reservoirs are in alignment with the first and second terminal ends of the central plate to facilitate formation of leak-proof seals between the reservoirs and the assembly components. An embodiment of the invention provides a plurality of sample wells incorporated with the cathode reservoir and constructed of rigid, electrically non-conducting material to provide a hard-well sample loading site for uniform and consistent sample injection. Another embodiment provides a mechanical biasing system incorporated with a cathode reservoir body to bias the assembly components together. The invention also provides a method of casting electrophoresis gels with the electrophoresis cassette provided herein.

Electrophoresis assembly and method of casting electrophoresis gels

The present invention provides high throughput screening Systems for identifying antifungal compounds. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.

Antifungal assay

The present invention provides high throughput screening systems for identifying antifungal compounds. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.

The invention provides isolated nucleic acid and amino acid sequences of cofilin, methods of screening for cofilin modulators using biologically active cofilin, and kits for screening for cofilin modulators.

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San Francisco, CA, United States of America

Corey E Nislow