University of Vermont and State Agricultural College

Other

University of Texas System

Genentech, Inc.

New York Medical College

University of Vermont

Grenentech, Inc.

Univ. of Vt and State Agricultural College

Cordell E Gross

Martin M Bednar

John Russell Falck

Michael Balazy

G Roger Thomas

Bruce A Keyt

Linda J Gross, Legal Representative

A method for improving clinical outcome in focal ischemic stroke in a mammal by increasing cerebral blood flow and/or reducing infarct size is described which involves administering an effective amount of an anti-CD18 antibody to the mammal, in the absence of removal of the arterial obstruction.

Co-administration of a tissue plasminogen activator, anti-CD11b antibody and anti-CD18 antibody in stroke

The present invention includes 16-HETE analogs which are agonists and antagonists of 16-HETE. The compositions may be formulated in pharmaceutically acceptable formulations. The invention also includes methods and products for inhibiting neutrophil adhesion and neutrophil aggregation using the 16-HETE agonists. One method of the invention involves the administration of a 16-HETE agonist in combination with a thrombolytic agent to a patient suffering from, thromboembolic stroke.

Methods and products related to 16-HETE analogs

The present invention includes 16-HETE analogs which are agonists and antagonists of 16-HETE. The compositions may be formulated in pharmaceutically acceptable formulations. The invention also includes methods and products for inhibiting neutrophil adhesion and neutrophil aggregation using the 16-HETE agonists. One method of the invention involves the administration of a 16-HETE agonist in combination with a thrombolytic agent to a patient suffering from thromboembolic stroke.

Methods and products relating to 16-HETE analogs

Arachidonic acid metabolite, 16-HETE

Methods and products are provided for treating thromboembolic stroke. A method involves the administration of a thienopyridine derivative in combination with a thrombolytic agent to a patient suffering from thromboembolic stroke. Preferably the thienopyridine derivative is ticlopidine and the thrombolytic agent is tPA. The method also involves the administration of a thrombolytic agent to a subject who already has circulating plasma levels of a thienopyridine derivative. The product is a pharmaceutical preparation of a thienopyridine derivative and a thrombolytic agent and a pharmaceutically acceptable carrier.

Thrombolytic agents and thienopyridine derivatives in acute stroke

Anti-CD18 antibodies in stroke

The present invention provides methods and products for inhibiting neutrophil adhesion and neutrophil aggregation. The invention includes a method for treating a subject to inhibit neutrophil adhesion and neutrophil aggregation by administering 16-hydroxyeicosatetraenoic acid (16-HETE) to the subject. 16-HETE is an arachidonic acid metabolite. The invention also includes a pharmaceutical preparation of 16-HETE.

Arachidonic acid metabolite, 16-hete

Growing community of inventors

Williston, VT, United States of America

Cordell E Gross