Codex Dna, Inc.

Febit Holding Gmbh

Febit Biotech Gmbh

Cord F Staehler

Peer Friedrich Staehler

Markus Beier

Joachim Jaeger

Jack Thacher Leonard

Raphael Carapito

Martin Mueller

Peter Nommensen

Tilo Strobelt

Johannes Frech

Mark Matzas

Manfred Mueller

The invention relates to methods and devices for preparing synthetic nucleic acids.

Synthesis of sequence-verified nucleic acids

The invention relates to an extraction method for isolating target molecules from a sample using a microfluidic carrier.

Microfluidic extraction method

In the case of a method for producing a fluid device with a fluid structure having an active height, a basic wafer is provided, which comprises a supporting substrate, an insulating layer on the supporting substrate and a patterned layer on the supporting substrate, the thickness of the patterned layer determining the active height of the fluid structure. Following this, the fluid structure is produced in the patterned layer of the basic wafer, said fluid structure extending through the semiconductor layer. A transparent wafer is then applied so that the fluid structure is covered. Subsequently, the supporting substrate and the insulating layer are removed from the back so that the fluid structure is exposed at a second surface of the patterned layer. Finally, a second transparent wafer is attached to the exposed second surface of the semiconductor layer so that the fluid structure is covered. The essential parameter of the fluid device, viz. the active height of the fluid structure, need no longer be controlled making use of the etching parameters, but is already determined by the specifications of the starting material, e.g. an SOI wafer. This means that economy-priced fluid devices can be produced with high precision.

Method for producing a fluid device, fluid device and analysis apparatus

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Weinheim, Germany

Cord F Staehler