The Johns Hopkins University

Koskimaki, Jacob E.

Rosca, Elena V.

Rivera, Corban G.

Tamiz, Amir P.

Popel, Aleksander S.

Pandey, Niranjan B.

Corban G Rivera

Aleksander S Popel

Niranjan B Pandey

Amir P Tamiz

Elena V Rosca

Jacob E Koskimaki

Bruce A Swett

Methods, systems, apparatuses, and computer programs, are described for generalizing a learned behavior across different tasks. In one aspect, a method includes obtaining first data that describes sensed attributes of a first environmental state, obtaining second data that defines a target end state after performance of a particular task, obtaining first output data generated by an affective experience module that represents a particular behavior to be performed by an agent system to complete the particular task in the environment, providing, as an input data to a machine learning model that has been trained to generate second output data indicative of a particular behavior that can be used to complete the task in the environment based on processing, by the machine learning model, of the input data, the input data comprising the first data, the second data, and the first output data, obtaining the second output data generated by the machine learning model, and selecting a particular behavior for enactment to complete the particular task based on the second output data.

Artificial intelligence reasoning system

Mimetic peptides having anti-angiogenic and anti-tumorigenic properties and methods of their use for treating cancer, ocular diseases, such as age-related macular degeneration, and other-angiogenesis-dependent diseases are disclosed. More particularly, active non-cysteine analogs (mimetics), which exhibit anti-angiogenic activity in endothelial cell proliferation, migration, adhesion, and tube formation assays, anti-migratory activity in human breast cancer cells in vitro, anti-angiogenic and anti-tumori-genic activity in vivo in breast cancer xenograft models, and age-related macular degeneration models are disclosed. The presently disclosed mimetic peptides also exhibit anti-lymphangiogenic and directly anti-tumorigenic properties.

Mimetic peptides derived from collagen type IV and their use for treating angiogenesis- and lymphangiogenesis- dependent diseases

Mimetic peptides derived from collagen type IV and their use for treating angiogenesis- and lymphangiogenesis-dependent diseases

Mimetic peptides having anti-angiogenic and anti-tumorigenic properties and methods of their use for treating cancer, ocular diseases, such as age-related macular degeneration, and other-angiogenesis-dependent diseases are disclosed. More particularly, active non-cysteine analogs (mimetics), which exhibit anti-angiogenic activity in endothelial cell proliferation, migration, adhesion, and tube formation assays, anti-migratory activity in human breast cancer cells in vitro, anti-angiogenic and anti-tumorigenic activity in vivo in breast cancer xenograft models, and age-related macular degeneration models are disclosed. The presently disclosed mimetic peptides also exhibit anti-lymphangiogenic and directly anti-tumorigenic properties.

Mimetic peptides derived from collagen type IV and their use for treating angiogenesis- and lymphagiogenesis-dependent diseases

Growing community of inventors

Baltimore, MD, United States of America

Corban G Rivera