Intrabiotics Pharmaceuticals, Inc.

Micrologix Biotech Inc.

Conway C Chang

Robert I Lehrer

Chee Liang Gu

Jie Chen

Deborah A Steinberg

Sylvia S L Harwig

David J Loury

Binh T Dang

Christopher J Baldwin

Reyna J Simon

John C Fiddes

Vladimir N Kokryakov

Robert R Webb

Peggy A Radel

Roger C Fu

Leo Gu

Sylvia Sl Harwig, Deceased

De Hwa Chao

The present invention provides a new class of broad-spectrum antimicrobial peptides effective against a wide variety of microbes, including bacteria, viruses, retroviruses, fungi, yeast and protozoa.

Parevins and tachytegrins

The present invention provides two new classes of polyene macrolide amide derivatives useful for treating or preventing fungal infections. The new polyene macrolide amide derivatives exhibit antifungal activity and are more water-soluble than conventional polyene antibiotics, such as amphotericin B and amphotericin B methyl ester.

Water-soluble amide derivatives of polyene macrolides and preparation and uses thereof

Peptide-based compounds containing four invariant cysteine residues which have been optionally oxidized to contain two intramolecular disulfide bonds, or modified forms where the cysteines are replaced are useful as preservatives and in preventing, treating, or ameliorating viral or microbial infection in animals and plants, and in inactivating endotoxin.

Protegrins

The present invention provides a new class of polyene macrolide derivatives useful for treating or preventing fungal infections. The new polyene macrolide derivatives exhibit surprisingly superior antifungal activity and water solubility compared to amphotericin B methyl ester (AME). In addition, the new polyene macrolide derivatives have improved water solubility and lower toxicity than both amphotericin B (AmB) and AME.

Derivatives of polyene macrolides and preparation and use thereof

The invention is directed to antimicrobial peptides related to naturally-occurring protegrin peptides, and methods of using the peptides in a variety of contexts, including the treatment or prevention of infections, and diseases related thereto.

Threonine-containing protegrins

The present invention provides methods and compositions suitable for treating oral mucositis in animals, including humans, with antimicrobial peptides such as protegrin peptides.

Compositions and methods for the prevention and treatment of oral

The invention is directed to antimicrobial peptides related to naturally-occurring protegrin peptides, and methods of using the peptides in a variety of contexts, including the treatment or prevention of infections.

Fine-tuned protegrins

The present invention provides cyclic peptides having broad spectrum antimicrobial activity. The peptides exhibit improved efficacy, bioavailability and/or serum half-life as compared with non-cyclized analogues.

Growing community of inventors

San Francisco, CA, United States of America

Conway C Chang