Dsm IP Assets B.v.

Tibotec Pharmaceuticals Ltd.

Dsm Assets B.v.

Constantinus Simon Maria Liebregts

Shahab Jahromi

Bart Rudolf Romanie Kesteleyn

Peter Jan Leonard Mario Quaedflieg

Robert Jan Vijn

Franciscus Alphons Marie Lommen

Karel Franciscus Hubertus Bonekamp

Jacob Hermanus Matheus Hero Kooistra

The invention provides a process for making a multilayer structure with a printed pattern by providing a film substrate having a crystalline organic compound layer, wherein the substrate optionally has a metal or metaloxide layer between the film substrate and the organic compound layer; applying a printed pattern via a plurality of printing rolls wherein the following steps are performed: optionally, applying as a first layer a primer over the whole surface, applying one or more ink layers on the film to obtain a printed pattern, and optionally, applying a cover varnish to obtain a film substrate with a crystalline organic compound layer and a printed pattern. The invention further relates to a laminate comprising a multilayer structure and a plastic film; the laminate preferably comprises a primer substantially covering the whole surface of the organic compound layer, on which primer the print is present.

Process for the preparation of a multilayer structure comprising a substrate, a crystalline organic barrier layer, and a printed pattern; and products obtained

The invention relates to a substrate comprising a layer of crystalline triazine with a protective compound having a retention of oxygen barrier at 85% RH of about 50% or better. The protective compound preferably contains an azine-formaldehyde or phenol-formaldehyde resin, preferably with an hydroxy-functional polymer, and is cured.

Substrates with barrier properties at high humidity

The present invention relates to methods for the preparation of diastereomerically pure (3R,3aS,6aR) hexahydro-furo[2,3-b]furan-3-ol as well as a novel intermediate, (3aR,4S,6aS) 4-methoxy-tetrahydro-furo[3,4-b]furan-2-one for use in said methods. More in particular the invention relates to a stereoselective method for the preparation of diastereomerically pure (3R,3aS,6aR) hexahydro-furo[2,3-b]furan-3-ol, as well as methods for the crystallization of (3aR,4S,6aS) 4-methoxy-tetrahydro-furo[3,4-b]furan-2-one and for the epimerization of (3aR,4R,6aS) 4-methoxy-tetrahydro-furo[3,4-b]-furan-2-one to (3aR,4S,6aS) 4-methoxy-tetrahydro-furo[3,4-b]furan-2-one.

Methods for the preparation of (3R,3aS,6aR) hexahydro-furo[2,3-b]furan-3-ol

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Helmond, Netherlands

Constantinus Simon Maria Liebregts