Pfizer Corporation

Cultor Corporation

Pfizer Products Inc.

Constantine Sklavounos

Harry A Watson, Jr

Robert W McLaughlin

Donald E Kuhla

Thomas C Crawford

Stephen Paul Gibson

Irving M Goldman

Philip D Hammen

Kerry Peter Mahon

Joanna Teresa Negri

John L Tucker

Richard S Lehner

Bharat K Shah

John Michael Maher

George Wayne Borden

Neil Demers

Charles William Murtiashaw, Deceased

Lulin Wei

Kerry P Mahon

Harry Austin Watson

Robert William Mclaughlin

Richard Shelton Lehner

Philip Dietrich Hammen

A method for removing impurities from racemic cis-6-phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol and purified cis-6-phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol useful as an estrogen agonist/antagonist.

Purified racemic lasofoxifene and purified lasofoxifene D-tartrate and a method for effective purification of racemic lasofoxifene

Process for preparing 4&Prime;-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives

Sulfoalkyl ether cyclodextrins are produced by a process of treating an unsubstituted cyclodextrin starting material with an alkyl sultone in the presence of a base. The base is added in a stepwise, pH controlled manner so that substantially the entire initial charge of cyclodextrin starting material is at least partially reacted. Additional base is then added to complete the reaction, and residual alkyl suftone is destroyed. The product advantageously contains low levels of both residual cyclodextrin and residual alkyl sultone.

Process for making a cyclodextrin

Process for natamycin recovery

Process and antiparasitic intermediates for doramectin

In the synthesis of biotin and decarboxybiotin, a more direct method for the conversion of 1,3-diacyl-4-(bromomethyl)-5-[(5-alkoxycarbonylpentanoyl) or hexanoyl]-4-imidazolin-2-ones to 1,3-diacyl-4-[(4-alkoxybutanoyl) or pentanoyl]-1H,3H-thieno (3,4-b)imidazol-2-one via the Bunte salt of the formula ##STR1## wherein R is (C.sub.1 -C.sub.5)alkanoyl or (C.sub.2 -C.sub.5) alkoxycarbonyl, X is methyl or (C.sub.2 -C.sub.5)alkoxycarbonyl an Y is an alkali metal.

Process for biotin intermediates

Biotin intermediates

Isobutylene carbonate and certain 1-substituted piperazine compounds are reacted in a process that forms 2-methyl-2-hydroxypropyl 4-substituted piperazine-1-carboxylate compounds which are medicinal agents or synthetic intermediates for such agents. The features of the process allow the preparation of an essentially pure 2-methyl-2-hydroxypropyl carboxylate compound.

Process for preparing 2-methyl-2-hydroxypropyl piperazine-1-carboxylate

Aromatic sulfonic acid salts of certain dipeptide sweeteners which are L-aspartyl-D-alaninamides or L-aspartyl-D-serinamides, each substituted on amide nitrogen with an organic radical having a highly branched carbon skeleton; the process for preparing said salts by crystallization; and utilization of this crystallization process in processes for the preparation, isolation and purification of said amides.

Process for preparation, isolation and purification of dipeptide

Processes for preparation, isolation and purification of dipeptide

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Waterford, CT, United States of America

Constantine Sklavounos