Dana-farber-cancer Institute Inc.

Cold Spring Harbor Laboratory

Pharma Mar, S.a.

Cold Spring Harbor Institute

Constantine S Mitsiades

Kenneth Carl Anderson

Nicholas Mitsiades

James Elliott Bradner

Scott William Lowe

Teru Hideshima

Christopher Vakoc

Johannes Zuber

Junwei Shi

Joseph R Bertino

Glynn Thomas Faircloth

Andrew L Kung

Daniel J Medina

Joseph Negri

Douglas W McMillin

Nicholos Mitsiades

Eugen Dhimolea

Scott W Lowe

Christopher R Vakoc

Daniel Medina

The invention provides compositions, methods, and kits for the treatment of acute myeloid leukemia in a subject.

Compositions and methods for treating leukemia

Systems, devices, and methods for generating, culturing, and using magnetically-controlled three-dimensional (3D) tissues are described. A magnetically-enabled transwell system for immobilizing and supplying perfusion to a 3D mini-tissue includes a cell culture vessel with at least a first chamber and a second chamber, the mini-tissue being disposed in the first chamber, and a perfusion mechanism defining an elongate perfusion channel with a proximal end in the first chamber and a distal end in fluid communication with the second chamber, with a magnetic element configured to immobilize a magnetically-controlled 3D mini-tissue such that the proximal end is in fluid communication with basolateral space of the immobilized mini-tissue.

Systems, apparatus, and methods related to magnetically-controlled three-dimensional tissue cultures

The present invention relates to therapeutic compositions for treating cancer or preventing the growth of cancer cells, e.g., tumor growth, in a subject. The present invention also relates to methods for treating cancer, e.g., inhibiting tumor growth, in a subject who has become resistant to treatment, by administering to a subject an effective amount of a proteasome inhibitor and an effective amount of a therapeutic agent, e.g., a chemotherapeutic agent. The present invention further relates to methods for purging bone marrow, i.e., removing cancer cells from bone marrow, by exposing the bone marrow cells to a proteasome inhibitor and a therapeutic agent, e.g., a chemotherapeutic agent.

Methods and compositions for treating cancer using proteasome inhibitors

Herein is provided methods and compositions for treating cancer. In one embodiment, a method is provided for treating a patient suffering from cancer, the method comprising administering to the patient an effective amount of reversine, reversine analog or reversine containing agent. In another embodiment, compositions comprising reversine are provided. Such compositions may further comprise additional active agents and other additives. The compositions and methods provided herein are useful, for example, in the area of medicine.

Use of reversine and analogs for treatment of cancer

The invention methods using a insulin-like growth factor receptor inhibitor to inhibit tumor cell growth in a subject in need thereof.

Methods for inhibiting tumor cell growth

Aplidine and aplidine analogues are used in the manufacture of a medicament for treating multiple myeloma.

Aplidine for multiple myeloma treatment

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Boston, MA, United States of America

Constantine S Mitsiades