Vertex Pharmaceuticals, Inc.

Vertex Pharmaceuticals (Canada) Incorporated

Viro Chem Pharma, Inc.

Constantin G Yannopoulos

Laval Chan Chun Kong

Sanjoy Kumar Das

Carl Poisson

Louis Vaillancourt

Guy Falardeau

Real Denis

Oswy Z Pereira

Monica Bubenik

John Patrick Maxwell

Simon Giroux

Mark A Morris

James A Henderson

Bingcan Liu

Rabindra Rej

Caroline Cadilhac

T Jagadeeswar Reddy

Irina Motorina

Jian Jim Wang

Albert Charles Pierce

Kevin Michael Cottrell

Govinda Rao Bhisetti

Ronald Lee Grey, Jr

Valerie Marone

Réal Denis

Luc J Farmer

Youssef L Bennani

Nghe Nguyen-Ba

Claudio F Sturino

Thumkunta Jagadeeswar Reddy

Christophe Moinet

Yeeman K Ramtohul

Marc Courchesne

Frederic Vallee

Julien Martel

Jean-Eric Lacoste

Youssef Laafiret Bennani

Wuyi Wang

Mohammad Arshad Siddiqui

Jean Bedard

Janek Szychowski

Stephanie Lessard

Charles Blais

Miguel St-Onge

Pierre-Andre Fournier

Camil Elie Sayegh

Bingan Liu

Youssef L Benanni

The present invention relates to compounds useful as inhibitors of the PAR-2 signaling pathway. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of GPCRs in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such GPCRs; and the comparative evaluation of new inhibitors of the PAR-2 signaling pathway. The compounds of this invention have formula I: wherein the variables are as defined herein.

Imidazopyridazines useful as inhibitors of the PAR-2 signaling pathway

Compounds represented by formula I or pharmaceutically acceptable salts thereof, wherein A, B, B', X, Y, R, R, R&#x2032;, R, R&#x2032;, R, R&#x2032;, R, R&#x2032;, m, n, or p are as defined herein, are useful for treating flaviviridae viral infections.

Analogues for the treatment or prevention of flavivirus infections

Compounds represented by formula I: or pharmaceutically acceptable salts and solvates thereof, wherein A, B, B', X, Y, R, R&#x2032;, R, R&#x2032;, R, R&#x2032;, R, R&#x2032;, R, m, n, or p are as defined herein, are useful for treating flaviviridae viral infections.

Benzimidazole analogues for the treatment or prevention of flavivirus infections

Compounds and methods for the treatment or prevention of flavivirus infections

Compounds represented by formula I: or pharmaceutically acceptable salts and solvates thereof, wherein R, X, Y, and Z are as defined herein, are useful for treating flaviviridae viral infections.

Thiophene analogues for the treatment or prevention of flavivirus infections

The present invention provides novel compounds represented by formula I: or pharmaceutically acceptable salts thereof useful for treating flaviviridae viral infection.

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Compounds according to formula (I): wherein R, R, R, n and X are defined as defined herein, and the pharmaceutically acceptable salts, hydrates and solvates thereof, are useful for the modulation of CCR5 chemokine receptor activity. Additionally, compounds according to Formula III: wherein Z, R', and R&#x2032;are defined as defined herein, and the pharmaceutically acceptable salts, hydrates and solvates thereof, are useful as intermediates for production of compounds that modulate CCR5 chemokine receptor activity.

Spirotropane compounds

Growing community of inventors

Ile Perrot, Canada

Constantin G Yannopoulos