Agence Nationale De Valorisation De La Recherche (anvar)

Constantin Bona

Louis A Chedid

Edgar Lederer

Jean-Francois Petit

Arlette, Born Adam

Chantal, Born Damais

Rita, Born Ciorbaru

Rita Ciorbaru Nee Sfartz

The invention relates to a process for obtaining agents having mitogenic and/or adjuvant properties, from Nocardia cells. According to this process Nocardia whole cells are subjected to a rupturing treatment of their walls within an aqueous medium, particularly distilled water. After the separation of the non-ruptured cells and of the wall fragments of the ruptured cells, mitogenic agents are extracted from the remaining aqueous phase. The fractions obtained are useful as laboratory reagents and for the production of medicamentous compositions in which they are associated with a pharmaceutical vehicle.

Process for obtaining agents having mitogenic and/or adjuvant properties

The invention pertains to a mitrogenic agent and to a process for obtaining same. It comprises the steps of cultivating Nocardiae cells, collecting them, subjecting them to a treatment for rupturing the integrity of their walls, such as by lysis, discarding the solid residue and collecting the aqueous fraction, causing the peptidoglycane fragments contained in this aqueous fraction to be separated therefrom and recovering the remaining fraction containing the mitogenic agent.

Water-soluble agents having mitogenic properties obtained from nocardia

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Paris, France

Constantin Bona