Other

Sanofi-Aventis

Azko Nobel

Constant Van Boeckel

Maurice Petitou

Jean Marc Herbert

Philippe Duchaussoy

Pierre Alexandre Driguez

Johannes Basten

Cornelia Dreef-Tromp

Peter Grootenhuis

Rogier Christian Buijsman

Martin De Kort

Dirk Gerrit Meuleman

Guy Jaurand

Synthetic polysaccharides are disclosed containing 8-24 monosaccharide units made up of a concatenation of disaccharides consisting of a uronic acid and a hexose, wherein the hydroxyl groups of the polysaccharides are etherified with a Calkyl group or esterified in the form of a sulpho group, each disaccharide being at least monoetherified; and salts thereof, are disclosed.

Synthetic polysaccharides, process for their preparation and pharmaceutical compositions containing them

The present invention relates compounds of the formula Aoligosaccharide-spacer-GpIIb/IIIa antagonist &#x2003;&#x2003;(A). The compounds of the invention have antithrombotic activity and can be used in treating or preventing thrombotic diseases.

Antithrombotic compound

A synthetic polysaccharide including an antithrombin III binding domain consisting of a concatenation of five monosaccharides supporting a total of two carboxylic acid functions and at least four sulpho groups, said domain being directly bound at the non-reducing end by a thrombin binding domain including a concatenation of 10-25 monosaccharide units selected from hexoses, pentoses or deoxy sugars of which all the hydroxyl groups are etherified by a C alkyl group or esterified in the form of sulpho groups, as well as salts and particularly pharmaceutically acceptable salts thereof, are disclosed.

Synthetic polysaccharides, preparation method therefor and pharmaceutical compositions containing same

Novel synthetic polysaccharides for use in the treatment of pathologies associated with a coagulation dysfunction.

Synthetic polysaccharides, their method of production and pharmaceutical compositions containing same

Growing community of inventors

Oss, Netherlands

Constant Van Boeckel