Other

Endacea, Inc.

Constance Neely Wilson

John Joseph Partridge

Paul Borron

The present invention relates to methods for treating and preventing renal impairment by administering to a subject a therapeutically effective amount of an Aadenosine receptor antagonist alone or in combination with at least one additional therapeutic agent. The invention further encompasses pharmaceutical compositions comprising an Aadenosine receptor antagonist alone or with, at least, one additional therapeutic agent in a pharmaceutically acceptable carrier. The pharmaceutical compositions of the invention find use in methods for treating and preventing renal impairment.

Methods and pharmaceutical compositions for preventing and treating renal impairment

This invention relates to compounds of formula (I), Wherein R-Rare defined in the Specification, their uses in the practice of medicine, their medicinal formulations, their use in medical diagnosis, and their preparation. 

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The present invention relates to methods of producing an antigenic response in which an antigen is contacted to an antigen-presenting cell, wherein the improvement comprises contacting the antigen-presenting cell with an Aadenosine receptor activating agent in an amount sufficient to increase the antigenic response of the antigen-presenting cell to the antigen. The present invention further provides methods, compositions, combination therapies, imaging techniques, and diagnostic kits that may improve the diagnosis, prognosis, and/or survival of cancer patients, pathogen-infected patients, and infectious or non-infectious immune-deficient patients.

Methods and compositions for producing antigenic responses

 The present invention provides novel adenosine receptor antagonists, more particularly, Aadenosine receptor antagonists of formula (I). Pharmaceutical compositions comprising an Aadenosine receptor antagonist of formula (I) and a pharmaceutically acceptable carrier are further provided. Compositions also include diagnostic assay-type probes comprising a novel Aadenosine receptor antagonist of formula (I) that is labeled or conjugated with radioactive or non-radioactive material. Methods for treating Aadenosine receptor related disorders comprising administering an Aadenosine receptor antagonist of formula I are also disclosed. The novel Aadenosine receptor antagonist compositions of formula (I) find further use in diagnostic and imaging methods.

Methods and compositions for treating and preventing sepsis are provided. The methods of the invention comprise administering to a subject a therapeutically effective amount of an A1 adenosine receptor antagonist in combination with an antibiotic agent. The invention further encompasses pharmaceutical compositions comprising a combination of an A1 adenosine receptor antagonist and an antibiotic agent in a pharmaceutically acceptable carrier. The pharmaceutical compositions of the invention find use in methods for treating and preventing sepsis.

Methods and pharmaceutical compositions for treating sepsis

Compounds of the general formula (I) are described: wherein A is a 5- or 6-membered aromatic or heteroaromatic ring. Compositions comprising such compounds and methods of use thereof are also described.

A1 adenosine receptor antagonists

The present invention provides novel adenosine receptor antagonists, more particularly, Aadenosine receptor antagonists of formula (I). Pharmaceutical compositions comprising an Aadenosine receptor antagonist of formula (I) and a pharmaceutically acceptable carrier are further provided. Compositions also include diagnostic assay-type probes comprising a novel Aadenosine receptor antagonist of formula (I) that is labeled or conjugated with radioactive or non-radioactive material. Methods for treating Aadenosine receptor related disorders comprising administering an Aadenosine receptor antagonist of formula (I) are also disclosed. The novel Aadenosine receptor antagonist compositions of formula (I) find further use in diagnostic and imaging methods. 

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Raleigh, NC, United States of America

Constance Neely Wilson