Harvard College

Massachusetts Institute of Technology

The Broad Institute, Inc.

Constance L Cepko

Chung Yiu Jonathan Tang

Wenjun Xiong

Aviv Regev

Phillip A Sharp

Steven Andrew McCarroll

Karthik Shekhar

Evan Macosko

Joshua Sanes

Sui Wang

Brian Anthony Rabe

Sylvain Lapan

Claudio Punzo

Bo Chen

Eugene Drokhlyansky

Irene Whitney

Paul Changelian

The present invention is directed to methods for the treatment or prevention of oxidative stress in a cell, e.g., photoreceptor cell, and methods for the treatment and prevention of disorders associated therewith by the administration of an agent, e.g., a nucleic acid molecule, which increases the expression and/or activity of an antioxidant defense protein.

Methods and compositions for inhibiting oxidative stress

Described herein are methods and compositions related to the diagnosis and treatment of COVID 19 and the detection of SARS-Cov-2.

Methods and compositions for the diagnosis and treatment of COVID 19

Disclosed herein are sensor systems, compositions comprising the sensor systems, and methods of using the same. In particular aspects, disclosed herein are sensor systems for a target intracellular ligand and uses thereof, e.g., in detection assays or in cell manipulation or therapeutic applications.

Sensor systems for target ligands and uses thereof

The present invention provides for methods of identifying cell types and cell subtypes from a biological sample or population of target cells. The methods further provide for determining cell type or cell subtype signatures. The method further provides for bipolar cell subtypes and markers and cell signatures thereof.

Method for determination and identification of cell signatures and cell markers

The invention provides systems to control gene expression or activity using target molecules.

Target molecules for transcriptional control systems

The present invention is directed to methods for the treatment or prevention of starvation in a cell, e.g., a neuronal cell, and methods for the treatment and prevention of disorders associated therewith by the administration of an agent, e.g., a nucleic acid molecule, which enhances the intracellular generation and/or uptake of glucose, pyruvate, lactate, and/or NADPH.

Methods for inhibiting starvation of a cell

Methods for inhibiting retinal cell death by altering expression of one or more of HDAC4, HDAC5, HDAC6, HDAC7, and HIF1&#x3b1; in a retinal cell are provided.

HDAC4 nucleic acid administration to treat retinal disease

Monoclonal antibodies, and a cell line characterized by its production of such monoclonal antibodies, demonstrating specific reactivity to an antigenic determinant possessed by a plurality of types of adenoviruses, a method of isolating such cell lines, and the use of such antibodies for diagnostic and therapeutic purposes as well as for identifying chemical compounds with similar properties, are disclosed.

Growing community of inventors

Boston, MA, United States of America

Constance L Cepko