Constance Therapeutics, Inc.

Constance Finley

Luke McKee

Haley Poole Bestwick

Paul A Roethle

Luke Mckee

Paul Roethle

The present invention provides cannabis oil extracts and compositions thereof, including cannabis oil compositions containing vitamin E, and methods for preparing the extracts and compositions. In some embodiments, the present invention provides a method for preparing a cannabis oil extract comprising eluting cannabinoids from cannabis plant material with a solvent to produce an eluate, filtering the eluate with a filter to produce a filtrate, evaporating the solvent from the filtrate with a distiller to produce a distillate, and purging the distillate under conditions sufficient to remove residual solvent, thereby preparing the extract. In some embodiments, the method further includes mixing a quantity of vitamin E with the extract to produce a cannabis oil composition.

Cannabis oil extracts and compositions

The present invention providesoil compositions, includingoil compositions containing vitamin E, and methods for preparing theoil compositions. In some embodiments, the invention provides a method for preparing aoil composition comprising eluting cannabinoids fromplant material with a solvent to produce an eluate; filtering the eluate with a filter to produce a filtrate; evaporating the solvent from the filtrate with a distiller to produce a distillate; and purging the distillate under conditions sufficient to remove residual solvent. In some embodiments, the method further includes mixing a quantity of vitamin E with the extract. Blendedoil compositions containing mixtures ofoil preparations are also described.

Cannabis oil compositions and methods for preparation thereof

A cannabinoid composition having an excipient including &#x3b1;-tocopherol and at least one isolated cannabinoid having a purity of greater than 80%. The &#x3b1;-tocopherol inhibits oxidation, regulates viscosity of the composition, and improves bioavailability of the cannabinoid. The composition includes a carrier oil mixed with the excipient and cannabinoid. In one embodiment, the at least one cannabinoid is an isolated cannabinoid having a greater than 80% purity, and preferably greater than 90% purity. The at least one cannabinoid is selected from the group consisting of phytocannabinoids, endocannabinoids, synthetic cannabinoids, and combinations thereof. The cannabinoid may be derived from plants other than, or synthesized from fungi, bacteria, yeast or other synthetic method. Preferably the &#x3b1;-tocopherol comprises at least 10% w/w of the composition.

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San Francisco, CA, United States of America

Constance Finley