Somatics, Inc.

Other

Conrad M Swartz

Richard Stephen Abrams

The compound carvedilol has the chemical formula: &ntilde;-1-(carbazol-4-yloxy)-3-&lsqb;&lsqb;2-(o-methyoxyphenoxy)ethyl&rsqb;amino&rsqb;-2-propanol. It exists in the form of optical isomers R- and S-carvedilol, and as mixtures of these isomers. It, or one of its optical isomers, is administered, preferably orally, several times per day in tablets of 3-25 mg for the treatment, prevention and clinical arrest of movement disorders associated with medications which block dopamine receptors, including many antipsychotic and antiemetic medications. Such movement disorders include tardive dyskinesia, tardive dystonia, and tardive akathisia. The compound carvedilol is also administered to improve the treatment of mental disorders in which dopamine-blocking medications are used, such as manic episodes, major depressive episodes, and psychoses such as schizophrenia and schizoaffective disorder.

Administration of carvedilol to mitigate tardive movement disorders, psychosis, mania, and depression

A combination of medicines are administered daily for the relief of the symptoms of an Anxiety Disorder or an Adjustment Disorder With Anxiety. The combination comprises a centrally-acting beta-blocker which passes the brain blood barrier, preferably the beta-blocker betaxolol, and a serotonin-enhancer, for example, the serotonin agonist buspirone or the serotonin reuptake inhibitor sertraline.

Centrally-acting beta-blockers and serotonin-enhancers for the treatment of anxiety disorders and adjustment disorders with anxiety

A free-standing device for the testing of ECT (electroconvulsive therapy) instruments, and for training doctors in using such instruments, includes circuits to generate electrical wave forms which simulate the EEG (electroencephalograph) detectable brain waves, EMG (electromyograph) muscle activity and heart beats of a patient undergoing ECT. In one embodiment the ECT output leads of the ECT instrument are plugged into the device, the training doctor selects the ECT current and the device generates response EEG and EMG waveforms. It also measures the current and displays its measurement as a test of the accuracy of the stimulus selection controls of the ECT instrument.

Electroconvulsive therapy testing and training device

In non-convulsive magnetic stimulation therapy a patient is treated with magnetic pulses from a coil placed proximate the patient's head as a treatment of certain neurologic and psychiatric disorders. A set of EEG (electroencephalograph) electrodes on the patient's scalp are switched on during pauses in the electrical pulse train to the coil. If epilepsy-like brain wave spikes and/or sharp waves are detected by the EEG, a warning is given, treatment is halted and an anti-convulsive medicine may be administered.

Prevention of seizure arising from medical magnetoictal non-convulsive

An oral protector, especially for use by patients during electroconvulsive therapy (ECT) consists of a flat unitary member which is preferably stamped from a flat sheet of material. The protector is elastic and formed of a closed-cell material, such as polyurethane plastic resin or artificial rubber. It has an elongated, generally elliptical shaped central opening which acts as an air passage.

Single-use oral protector especially for use in electroconvulsive therapy

In medical convulsive therapy (CV), comprising electroconvulsive therapy (ECT) and magnetoconvulsive therapy (MCT), a computer system is used to analyze the effectiveness of the treatment. In one embodiment the effectiveness is determined by measuring the physiological effects on the heart (ECG) muscles (EMG) and brain (EEG).

Convulsive therapy apparatus to stimulate and monitor the extent of

A magnetic induction coil is placed next to the scalp of a patient. A pulse train of high energy electrical waves is flowed through the induction coil to produce a sufficiently strong magnetic field to generate currents in the patient's brain for the therapy of neurologic or psychiatric illnesses. These currents induced in the brain cause multifocal neuronal discharge to induce a generalized convulsive neuronal discharge.

Medical magnetoictal therapy

The compound betaxolol has the chemical formula:

Betaxolol hydrochloride for the treatment of anxiety disorders

A medical device includes a magnetic stimulator having a magnetic induction coil which is placed next to the scalp of a patient. A pulse train of high energy electrical waves is flowed through the induction coil to produce a sufficiently strong magnetic field to generate currents in the patient's brain for the therapy of psychiatric illnesses. These currents induced in the brain are below the minimum needed to induce a convulsive brain seizure. The device includes an ECG (electrocardiograph) to monitor the electrical activity of the patient's heart and an EEG (electroencephalograph) to monitor the patient's electrical brain waves.

Medical magnetic non-convulsive stimulation therapy

An electronic method and apparatus in electroconvulsive therapy (ECT) to automatically measure the electrical dosage of an ECT device at the time of stimulus and to prevent delivery to the patient of a dosage that is substantially (e.g., more than 5%, or 25 millicoulombs [mC], or 5 joules [J]) larger than the dosage selected by the operator. When the measured dosage varies more or less than a selected limited amount, or proportion, from the stimulus dial setting (e.g., 5% or 25 mC or 5 J), visible and/or audible signals are triggered and the device is blocked from delivering further stimuli without first being reset.

Safety monitor circuit for an ECT device and method

In electroconvulsive therapy (ECT) the duration of the generated skeletal muscle, heart and brain wave activity during the administration of the electrically induced therapeutic seizures is automatically monitored. The ECT device includes a special purpose electromyograph (EMG) to detect isolated muscle activity and, in one embodiment, an electrocardiograph (ECG) to detect heart-beat intervals, and in another embodiment also includes an electroencephalograph (EEG) system to detect an EEG parameter of the electrically induced EEG seizure. The detected voltage from the EMG, ECG and EEG are converted to digital data and compared to a set of threshold reference values previously obtained from the same patient. The operator is informed by a display, or auditory signal, if the selected parameters have crossed the predetermined threshold reference value and the time period, since termination of the ECT that each parameter has taken to reach the reference value.

Electroconvulsive therapy apparatus and method for monitoring patient

A method and systen in electroconvulsive therapy (ECT) to automatically monitor and display the occurrence and the duration of the seizure activity generated during the administration of electrically induced therapeutic seizures. The ECT device includes a special-purpose electroencephaloraph (EEG) system to detect a specific EEG parameter (e.g. integrated voltage) of the electrically induced EEG seizure. The detected integrated voltage is converted to digital data and compared to a threshold reference value previously obtained from the same patient. The operator is informed by an electronic alphanumeric elapsed time display or indications on a moving strip chart paper record, or oscilloscope CRT screen, when the parameter has crossed the predetermined threshold reference value and how long since the termination of the ECT the parameter has taken to reach the reference value.

Electroconvulsive therapy apparatus and method for automatic monitoring

A method and system in electroconvulsive therapy (ECT) to automatically monitor and display the occurrence and the duration of the seizure activity generated during the administration of the electrically induced therapeutic seizures. The ECT device includes a special-purpose electroencephalograph (EEG) system to detect a specific EEG parameter (e.g. integrated voltage) of the electrically induced EEG seizure. The detected integrated voltage is converted to digital data and compared to a threshold reference value previously obtained from the same patient. The operator is informed by an electronic alphanumeric elapsed time display or indications on a moving strip chart paper record, or oscilloscope CRT screen, when the parameter has crossed the predetermined threshold reference value and how long since the termination of the ECT the parameter has taken to reach the reference value.

A medical method and system in electroconvulsive therapy (ECT) uses a disposable electrode, which does not use a liquid, such as conductive gel or saline solution. The electrode is a flexible multi-layer pad having an adhesive surface which is covered by a removable cover sheet. The pad comprises a layer of adhesive non-liquid conductive hydrogel, a thin conductive plastic film layer, a conductive metal foil layer connected to a wire lead, and an insulative plastic layer, preferably a plastic foam.

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Greenville, NC, United States of America

Conrad M Swartz