Corning Incorporated

Connor Thomas O'Malley

Joseph Michael Matusick

Kevin Patrick McNelis

Keith Raymond Gaylo

Steven Edward DeMartino

John Stephen Peanasky

James Ernest Webb

Patrick Joseph Cimo

Douglas Miles Noni, Jr

Sinue Gomez-Mower

Amber Leigh Tremper

Christy Lynn Chapman

Jared Seaman Aaldenberg

Weirong Jiang

Christie Leigh McCarthy

Kristen Dae Waight

Eric Lewis Allington

Bryan James Musk

Robert Anthony Schaut

Lewis Kirk Klingensmith

Shivani Rao Polasani

Michael Clement Ruotolo, Jr

Adam Robert Sarafian

Ljerka Ukrainczyk

Kevin Lee Wasson

William Brashear Mattingly, Iii

Karl David Ehemann

Matthew Daniel Trosa

Steven Robert Wagner

Christelle Ruby Barnard

Elias Panides

David John McEnroe

Alicia Marie Gallagher

Michael Clement Ruotolo

Eric Michael Gross

William Brashear Iii Mattingly

Methods for providing feedback control of converters for converting glass tubes to glass articles include a model predictive control framework. The methods include operating the converter, providing target values for attributes of the glass articles or glass tubes, measuring the attributes for the glass articles and glass tubes, conditioning the measurement data to remove outlier data points and calculating statistics representative of the measured attributes, and determine updated settings for one or more process parameters from the previous settings, the statistical properties, and the target values, where the updated settings are those that minimize an objective control function for the converter. The methods further include adjusting the process parameters to the updated settings. The model predictive control framework enables feedback control of the converter that compensates for disturbances that act on the process.

Feedback control systems and methods for glass tube converting processes

A glass cartridge comprises a cylindrical body portion comprising an outer diameter Dand an average sidewall thickness T, the cylindrical body portion having a first end and a second end opposite the first end; an opening at the first end of the cylindrical body portion; a shoulder extending radially inward from the second end of the cylindrical body portion; and a neck extending from the shoulder and comprising an outer neck diameter Nthat is less than the outer diameter Dof the cylindrical body portion. The average wall thickness Tis less than or equal to 0.85*s, wherein sis a wall thickness of a standard glass cartridge defined by ISO 13926-1:2004 having an outer diameter dthat is closer to the outer diameter Dthan the outer diameter dof any other standard glass cartridge defined by ISO 13926-1:2004.

Glass containers for storing pharmaceutical compositions

A system for producing articles from glass tube includes a converter having a base with a plurality of processing stations and a turret moveable relative to the base. The turret indexes a plurality of holders for holding the glass tubes successively through the processing stations. The system further includes a thermal imaging system that includes a thermal imager coupled to the turret for movement with the turret. The thermal imaging system may also include a mirror coupled to the thermal imager and positioned to reflect infrared light from one of the plurality of holders to the thermal imager. The thermal imaging system may measure one or more characteristics of the glass tube during the conversion process. Processes for controlling the converter using the thermal imaging system to measure one or more process variables are also disclosed.

Systems and methods for measuring the temperature of glass during tube conversion

Disclosed herein are glass pharmaceutical vials having sidewalls of reduced thickness. In embodiments, the glass pharmaceutical vial may include a glass body comprising a sidewall enclosing an interior volume. An outer diameter D of the glass body is equal to a diameter di of a glass vial of size X as defined by ISO 8362-1, wherein X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1. However, the sidewall of the glass pharmaceutical vial comprises an average wall thickness Tthat is less than or equal to 0.85*s, wherein sis a wall thickness of the glass vial of size X as defined by ISO 8362-1 and X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1.

Disclosed herein are glass pharmaceutical vials having sidewalls of reduced thickness. In embodiments, the glass pharmaceutical vial may include a glass body comprising a sidewall enclosing an interior volume. An outer diameter D of the glass body is equal to a diameter dof a glass vial of size X as defined by ISO 8362-1, wherein X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1. However, the sidewall of the glass pharmaceutical vial comprises an average wall thickness Tthat is less than or equal to 0.85*s, wherein sis a wall thickness of the glass vial of size X as defined by ISO 8362-1 and X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1.

Methods for controlling a converter for converting glass tubes to glass articles include preparing condition sets including settings for a plurality of process parameters, operating the converter to produce glass articles, measuring attributes of the glass articles, operating the converter at each of the condition sets, associating each glass article with a condition set used to produce the glass article and the attributes measured, developing operational models from the attributes measured and the condition sets, determining run settings for each of the plurality of process parameters based on the operational models, and operating the converter with each of the process parameters set to the run settings determined from the operational models.

Converter systems and methods for controlling operation of glass tube converting processes

Methods for producing articles from a glass tube include securing a working end of the glass tube in a glass tube holder of a converter having a plurality of processing stations including a heating station and a forming station. An initial length of the glass tube includes a plurality of serial segments, each of the plurality of serial segments corresponding to one article and having an article number. The methods include heating the working end of the glass tube in the heating station, adjusting an amount of heating of the glass tube in the heating station based on the article number at the working end of the glass tube, and forming a feature of the article in the forming station. Adjusting the amount of heating based on the article number reduces variation in tube temperature, article dimensions, or both, from one article number to the next article number.

Methods to control thermal variation during tube consumption in glass tube converting

Systems for producing articles from glass tube include a converter having a base with a plurality of processing stations and a turret moveable relative to the base. The turret indexes a plurality of holders for holding the glass tubes successively through the processing stations. The systems further include a gas flow system or a suction system for producing a flow of gas through the glass tube during one or more heating, forming, separating or piercing operations. The flow of gas through the glass tube produced by the gas flow system or suction system may be sufficient to evacuate or purge volatile constituents of the glass from the glass tube and/or pierce a meniscus formed on the glass tube during separation, thereby reducing the Surface Hydrolytic Response (SHR) of the interior surface of the glass tube and articles made therefrom.

Systems and methods for minimizing SHR from pharmaceutical part converting using pulsed ejection

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Painted Post, NY, United States of America

Connor Thomas O'Malley