Janssen Pharmaceutica Nv

Other

Connor L Martin

Steven D Goldberg

Xiaohua Xue

Craig R Woods

Elizabeth G Fennema

David A Kummer

Steven P Meduna

Anne Fourie

Rachel T Nishimura

Virginia M Tanis

Stefan McCarver

Alexander Valdes

Timothy B Rhorer

Douglas Behenna

Ronald L Wolin

John M Keith

Alexander Raymond Rovira

Steven Loskot

Hariharan Venkatesan

Alec D Lebsack

Kelly J McClure

William Moore Jones

Charlotte Pooley Deckhut

Garret Martin

Alexander Rovira

Anne M Fourie

Kelly Mcclure

The present application discloses compounds having the following formula: or pharmaceutically acceptable salts thereof, wherein R, R, R, Rand Rare defined in the specification, as well as methods of making and using the compounds disclosed herein for treating or ameliorating an IL-17 mediated syndrome, disorder and/or disease.

Imidazopyridazines as modulators of IL-17

Systems and methods are provided for a magnetic coupling shade system for boats. The magnetic coupling shade system features a sheet of material that includes magnetic portions coupled with magnets disposed in locations of a boat. The locations of the boat include any of the hull, deck, superstructure, hardtop, or any other suitable surface of the boat. Magnets located on the hull are located within the interior of the hull. The sheet extends from the top to either or both of the port and starboard sides. The sheet can include a variety of materials, and a window portion for viewing through the sheet. In some embodiments, the window portion includes an entirety of the sheet with the magnetic portions attached to opposite edges of the window portion. The sheet is configured to be detached from the magnets and either suspended overhead or rolled upward when not in use.

Magnetic coupling shade system for boats

The present invention comprises compounds of Formula I. wherein:R, R, R, R, R, R, R, Q, and Qare defined in the specification. The invention also comprises a method of treating or ameliorating a ROR-&#x3b3;-t mediated syndrome, disorder or disease, including wherein the syndrome, disorder or disease is selected from the group consisting of rheumatoid arthritis, psoriatic arthritis, and psoriasis. The invention also comprises a method of modulating ROR&#x3b3;t activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.

Phenyl and pyridinyl substituted imidazoles as modulators of ROR&#x3b3;T

The present invention comprises compounds of Formula I. wherein:R, R, R, R, R, and Q are defined in the specification. The invention also comprises a method of treating or ameliorating a ROR-&#x3b3;-t mediated syndrome, disorder or disease, including wherein the syndrome, disorder or disease is selected from the group consisting of rheumatoid arthritis, psoriatic arthritis, and psoriasis. The invention also comprises a method of modulating ROR&#x3b3;t activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.

Pyridinyl pyrazoles as modulators of ROR&#x3b3;T

The present invention comprises compounds of Formula I. wherein:R, Q, R, R, R, R, A, and Aare defined in the specification. The invention also comprises a method of treating or ameliorating a ROR-&#x3b3;-t mediated syndrome, disorder or disease, including wherein the syndrome, disorder or disease is selected from the group consisting of rheumatoid arthritis, psoriatic arthritis, and psoriasis. The invention also comprises a method of modulating ROR&#x3b3;t activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.

6-aminopyridin-3-yl pyrazoles as modulators of RORgT

The present invention comprises compounds of Formula I. wherein: The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein the syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating ROR&#x3b3;t activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.

6-aminopyridin-3-yl thiazoles as modulators of ROR&#x3b3;T

The present invention comprises compounds of Formula I. wherein:R, R, R, R, R, R, R, and Q are defined in the specification. The invention also comprises a method of treating or ameliorating a ROR-&#x3b3;-t mediated syndrome, disorder or disease, including wherein the syndrome, disorder or disease is selected from the group consisting of rheumatoid arthritis, psoriatic arthritis, and psoriasis. The invention also comprises a method of modulating ROR&#x3b3;t activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.

Phenyl substituted pyrazoles as modulators of ROR&#x3b3;t

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San Diego, CA, United States of America

Connor L Martin